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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pax9tm1Hpt
targeted mutation 1, Heiko Peters
MGI:3612401
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pax9tm1Hpt/Pax9tm1Hpt involves: 129S2/SvPas * C57BL/6 MGI:3612954
ht2
Pax9tm1Hpt/Pax9tm1Rbal involves: 129 * C57BL/6 * CD-1 MGI:3612955


Genotype
MGI:3612954
hm1
Allelic
Composition
Pax9tm1Hpt/Pax9tm1Hpt
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax9tm1Hpt mutation (0 available); any Pax9 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic (J:104121)
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw (J:104121)
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic (J:104121)
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw (J:104121)
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed (J:104121)
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed (J:104121)
• in most cases the lower incisors are absent (J:104121)
• in most cases the lower incisors are absent (J:104121)
• the lower first molars show significant attrition and formation of reparative and reactionary dentin (J:104121)
• the lower first molars show significant attrition and formation of reparative and reactionary dentin (J:104121)
• the upper and lower third molars are unilaterally or bilaterally absent (J:104121)
• the upper and lower third molars are unilaterally or bilaterally absent (J:104121)
• lower third molars and incisors may fail to erupt (J:104121)
• lower third molars and incisors may fail to erupt (J:104121)
• a mixture of reactionary and reparative dentin seen in molars (J:104121)
• a mixture of reactionary and reparative dentin seen in molars (J:104121)
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen (J:104121)
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen (J:104121)

endocrine/exocrine glands
N
• thymus morphology is normal and no signs of defective parathyroid or ultimobranchial body function (as shown by normal calcium and phosphate homeostasis) are seen (J:104121)
• thymus morphology is normal and no signs of defective parathyroid or ultimobranchial body function (as shown by normal calcium and phosphate homeostasis) are seen (J:104121)

growth/size/body
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic (J:104121)
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw (J:104121)
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic (J:104121)
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw (J:104121)
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed (J:104121)
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed (J:104121)
• in most cases the lower incisors are absent (J:104121)
• in most cases the lower incisors are absent (J:104121)
• the lower first molars show significant attrition and formation of reparative and reactionary dentin (J:104121)
• the lower first molars show significant attrition and formation of reparative and reactionary dentin (J:104121)
• the upper and lower third molars are unilaterally or bilaterally absent (J:104121)
• the upper and lower third molars are unilaterally or bilaterally absent (J:104121)
• lower third molars and incisors may fail to erupt (J:104121)
• lower third molars and incisors may fail to erupt (J:104121)
• a mixture of reactionary and reparative dentin seen in molars (J:104121)
• a mixture of reactionary and reparative dentin seen in molars (J:104121)
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen (J:104121)
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen (J:104121)

Mouse Models of Human Disease
OMIM ID Ref(s)
Tooth Agenesis, Selective, 3; STHAG3 604625 J:104121




Genotype
MGI:3612955
ht2
Allelic
Composition
Pax9tm1Hpt/Pax9tm1Rbal
Genetic
Background
involves: 129 * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax9tm1Hpt mutation (0 available); any Pax9 mutation (1 available)
Pax9tm1Rbal mutation (0 available); any Pax9 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• underrepresented at weaning (J:104121)
• underrepresented at weaning (J:104121)

craniofacial
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed (J:104121)
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed (J:104121)
• in the upper incisors ameloblasts are present at 2 months of age but absent by 5 months (J:104121)
• in the upper incisors ameloblasts fail to elongate and produce only a thin layer of pre-enamel (J:104121)
• in the upper incisors ameloblasts are present at 2 months of age but absent by 5 months (J:104121)
• in the upper incisors ameloblasts fail to elongate and produce only a thin layer of pre-enamel (J:104121)
• at P0 all third molars are arrested prior to the bud stage and the lower second molars are arrested at the bud stage (J:104121)
• at P0 the lower first molars have reached the bell stage but lack polarization and alignment of the ameloblasts and odontoblasts (J:104121)
• at P0 all third molars are arrested prior to the bud stage and the lower second molars are arrested at the bud stage (J:104121)
• at P0 the lower first molars have reached the bell stage but lack polarization and alignment of the ameloblasts and odontoblasts (J:104121)
• at P0 the upper first and second molars are mostly growth retarded (J:104121)
• at P0 the upper first and second molars are mostly growth retarded (J:104121)
• all mice lack lower incisors (J:104121)
• all mice lack lower incisors (J:104121)
• the lower first molars show significant attrition and formation of reparative dentin (J:104121)
• the lower first molars show significant attrition and formation of reparative dentin (J:104121)
• the upper third and lower second and third molars are unilaterally or bilaterally absent (J:104121)
• the upper third and lower second and third molars are unilaterally or bilaterally absent (J:104121)
• lower third molars and incisors fail to erupt and other teeth in the lower jaw may also fail to erupt (J:104121)
• lower third molars and incisors fail to erupt and other teeth in the lower jaw may also fail to erupt (J:104121)
• irregular dentin formation is indicated by the presence of 'contour lines of Owen' (J:104121)
• irregular dentin formation is indicated by the presence of 'contour lines of Owen' (J:104121)
• the upper incisors lack enamel; however enamel formation in the molars is normal (J:104121)
• the upper incisors lack enamel; however enamel formation in the molars is normal (J:104121)
• more severe tooth loss than in Pax9tm1Hpt homozygotes with all mice lacking at least 4 teeth (oligodontia) and some lacking all lower teeth (J:104121)
• more severe tooth loss than in Pax9tm1Hpt homozygotes with all mice lacking at least 4 teeth (oligodontia) and some lacking all lower teeth (J:104121)

growth/size/body
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed (J:104121)
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed (J:104121)
• in the upper incisors ameloblasts are present at 2 months of age but absent by 5 months (J:104121)
• in the upper incisors ameloblasts fail to elongate and produce only a thin layer of pre-enamel (J:104121)
• in the upper incisors ameloblasts are present at 2 months of age but absent by 5 months (J:104121)
• in the upper incisors ameloblasts fail to elongate and produce only a thin layer of pre-enamel (J:104121)
• at P0 all third molars are arrested prior to the bud stage and the lower second molars are arrested at the bud stage (J:104121)
• at P0 the lower first molars have reached the bell stage but lack polarization and alignment of the ameloblasts and odontoblasts (J:104121)
• at P0 all third molars are arrested prior to the bud stage and the lower second molars are arrested at the bud stage (J:104121)
• at P0 the lower first molars have reached the bell stage but lack polarization and alignment of the ameloblasts and odontoblasts (J:104121)
• at P0 the upper first and second molars are mostly growth retarded (J:104121)
• at P0 the upper first and second molars are mostly growth retarded (J:104121)
• all mice lack lower incisors (J:104121)
• all mice lack lower incisors (J:104121)
• the lower first molars show significant attrition and formation of reparative dentin (J:104121)
• the lower first molars show significant attrition and formation of reparative dentin (J:104121)
• the upper third and lower second and third molars are unilaterally or bilaterally absent (J:104121)
• the upper third and lower second and third molars are unilaterally or bilaterally absent (J:104121)
• lower third molars and incisors fail to erupt and other teeth in the lower jaw may also fail to erupt (J:104121)
• lower third molars and incisors fail to erupt and other teeth in the lower jaw may also fail to erupt (J:104121)
• irregular dentin formation is indicated by the presence of 'contour lines of Owen' (J:104121)
• irregular dentin formation is indicated by the presence of 'contour lines of Owen' (J:104121)
• the upper incisors lack enamel; however enamel formation in the molars is normal (J:104121)
• the upper incisors lack enamel; however enamel formation in the molars is normal (J:104121)
• more severe tooth loss than in Pax9tm1Hpt homozygotes with all mice lacking at least 4 teeth (oligodontia) and some lacking all lower teeth (J:104121)
• more severe tooth loss than in Pax9tm1Hpt homozygotes with all mice lacking at least 4 teeth (oligodontia) and some lacking all lower teeth (J:104121)

endocrine/exocrine glands
N
• thymus morphology is normal and no signs of defective parathyroid or ultimobranchial body function (as shown by normal calcium and phosphate homeostasis) are seen (J:104121)
• thymus morphology is normal and no signs of defective parathyroid or ultimobranchial body function (as shown by normal calcium and phosphate homeostasis) are seen (J:104121)

Mouse Models of Human Disease
OMIM ID Ref(s)
Tooth Agenesis, Selective, 3; STHAG3 604625 J:104121





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory