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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smc1atm1Mbk
targeted mutation 1, Michael B Kastan
MGI:3612278
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Rad50tm2Jpt/Rad50tm2Jpt
Smc1atm1Mbk/Smc1atm1Mbk
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 MGI:3615687
ot2
Smc1atm1Mbk/Y involves: 129S1/Sv * C57BL/6 MGI:3615660


Genotype
MGI:3615687
cx1
Allelic
Composition
Rad50tm2Jpt/Rad50tm2Jpt
Smc1atm1Mbk/Smc1atm1Mbk
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (34 available)
Smc1atm1Mbk mutation (1 available); any Smc1a mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double homozygotes are indistinguishable from homozygous Rad50tm2Jpt mice with respect to survival and die within 5 months after birth

hematopoietic system
• double homozygotes are indistinguishable from homozygous Rad50 mice with respect to hematopoietic cell numbers
• pro-B cell numbers are similar to that in homozygous Rad50 mice
• double-negative T cell numbers are similar to that in homozygous Rad50 mice
• 26 of 27 develop anemia
• macrophage numbers are similar to that in homozygous Rad50 mice

immune system
• pro-B cell numbers are similar to that in homozygous Rad50 mice
• double-negative T cell numbers are similar to that in homozygous Rad50 mice
• macrophage numbers are similar to that in homozygous Rad50 mice




Genotype
MGI:3615660
ot2
Allelic
Composition
Smc1atm1Mbk/Y
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc1atm1Mbk mutation (1 available); any Smc1a mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• MEFs exhibit a defective S-phase checkpoint after ionizing radiation induced DNA damage
• MEFs exhibit decreased cell survival following exposure to the alkylating agent, methylmethanesulfonate
• MEFs exhibit decreased cell survival following exposure to ionizing radiation
• MEFs exhibit a slower disappearance of chromosomal breaks after ionizing radiation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory