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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Crebbptm2Pkb
targeted mutation 2, Paul K Brindle
MGI:3612048
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Crebbptm2Pkb/Crebbptm2Pkb (B6.129-Crebbptm2Pkb x 129-Crebbptm2Pkb)F1 MGI:3626196
hm2
Crebbptm2Pkb/Crebbptm2Pkb (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1 MGI:5766814
hm3
Crebbptm2Pkb/Crebbptm2Pkb involves: 129P2/OlaHsd * C57BL/6 MGI:3626193
ht4
Crebbptm2Pkb/Crebbp+ involves: 129P2/OlaHsd * C57BL/6 MGI:3626195
cx5
Crebbptm2Pkb/Crebbp+
Ep300tm3Pkb/Ep300+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:3626197
cx6
Crebbptm2Pkb/Crebbptm2Pkb
Ep300tm3Pkb/Ep300tm3Pkb
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:3626198
cx7
Crebbptm2Pkb/Crebbp+
Ep300tm3Pkb/Ep300tm3Pkb
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:3626199
cx8
Crebbptm2Pkb/Crebbp+
Tg(IghMyc)22Bri/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3626200


Genotype
MGI:3626196
hm1
Allelic
Composition
Crebbptm2Pkb/Crebbptm2Pkb
Genetic
Background
(B6.129-Crebbptm2Pkb x 129-Crebbptm2Pkb)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: about 25% of homozygotes survive to maturity on this background

growth/size/body
• surviving homozygotes are growth retarded

craniofacial
• homozygotes that survive to maturity have craniofacial defects




Genotype
MGI:5766814
hm2
Allelic
Composition
Crebbptm2Pkb/Crebbptm2Pkb
Genetic
Background
(B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit impaired long-term recognition memory but intact short-term memory
• in the resident-intruder paradigm, mice how much less aggression than wild-type males
• in the elevated-plus-maze experiments, mutants spend less time in the closed arm and enter the closed arm less frequently, indicating less anxiety
• mice spend increased time self-grooming
• however, mice show a normal pain response in a hot plate assay
• although mutants show normal latency to fall from an accelerating rotard, when the rod is modified with tape to reduce surface friction, mutants fall sooner when they walk with, but not against, the direction of the rotating rod, suggesting impaired motor function
• in the wire hang assay, mice fall from the wire more quickly than controls and exhibit reduced grip strength
• in the open-field test, mice rear more frequently
• in the open-field test, mice travel father than wild-type mice, rear more frequently, and spend more time in the central zone, indicating hyperactivity
• mice exhibit stereotyped forelimb movements
• in the nesting behavior assay, mice show poor nest building abilities
• mice spend less time interacting with a mouse introduced into the chamber and show reduced preference for a novel versus a familiar mouse, indicating impaired social interaction

craniofacial
• E18.5 mutants show developmental defects in the occipital bone
• partial penetrance of hyperdontia
• 100% penetrance of shortened nasal bones
• blunt snouts

growth/size/body
• partial penetrance of hyperdontia
• blunt snouts

mortality/aging
N
• normal lifespan after weaning

nervous system
• post-tetanic potentiation at excitatory synapses between CA3 and CA1 pyramidal neurons is enhanced
• however, basal synaptic transmission and presynaptic function are intact

skeleton
• E18.5 mutants show developmental defects in the occipital bone
• partial penetrance of hyperdontia
• 100% penetrance of shortened nasal bones
• E18.5 mutants show bifurcation of the xyphoid process

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:230850




Genotype
MGI:3626193
hm3
Allelic
Composition
Crebbptm2Pkb/Crebbptm2Pkb
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• essentially all homozygotes die shortly after birth; one homozygote out of 651 total mice survived to adulthood but was runted; at E18.5 and P0.5, homozygotes are detected at near the expected ratio

craniofacial
• about 50% of homozygotes have cleft secondary palate

respiratory system
• at E18.5 mutants have thickened interstitial septa
• on a mixed background, E18.5 homozygotes have smaller lungs than wild-type or homozygous Ep300tm3Pkb mutants
• mutants have decreased alveolar airspaces

digestive/alimentary system
• about 50% of homozygotes have cleft secondary palate

growth/size/body
• about 50% of homozygotes have cleft secondary palate




Genotype
MGI:3626195
ht4
Allelic
Composition
Crebbptm2Pkb/Crebbp+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• there is a decrease of ~30% in number of heterozygotes seen at adulthood compared to expected




Genotype
MGI:3626197
cx5
Allelic
Composition
Crebbptm2Pkb/Crebbp+
Ep300tm3Pkb/Ep300+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (72 available)
Ep300tm3Pkb mutation (2 available); any Ep300 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• compound mutants are smaller than littermates

craniofacial
• some compound heterozygotes have craniofacial defects




Genotype
MGI:3626198
cx6
Allelic
Composition
Crebbptm2Pkb/Crebbptm2Pkb
Ep300tm3Pkb/Ep300tm3Pkb
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (72 available)
Ep300tm3Pkb mutation (2 available); any Ep300 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3626199
cx7
Allelic
Composition
Crebbptm2Pkb/Crebbp+
Ep300tm3Pkb/Ep300tm3Pkb
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (72 available)
Ep300tm3Pkb mutation (2 available); any Ep300 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• viable embryos can be recovered at E14.5




Genotype
MGI:3626200
cx8
Allelic
Composition
Crebbptm2Pkb/Crebbp+
Tg(IghMyc)22Bri/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm2Pkb mutation (2 available); any Crebbp mutation (72 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• on a hybrid background presence of a single Crebbtm2Pkb allele decreased the median survival time by about 8-10 weeks compared to wild-type transgenic littermates





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory