Analysis Tools
nervous system
|
• dentate gyrus granule cells in brain slice culture show a gain-of-function for BK channels that sharpens action potentials and supports higher firing rates
|
|
Allele Symbol Allele Name Allele ID |
Kcnmb4tm1Rwa targeted mutation 1, Richard W Aldrich MGI:3611890 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• dentate gyrus granule cells in brain slice culture show a gain-of-function for BK channels that sharpens action potentials and supports higher firing rates
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• chronic video electroencephalogram monitoring of freely moving mice show interictal spike discharges appearing initially over the temporal cortex that spread into a fully generalized seizure episode in the neocortex
• tonic or clonic behaviors are not seen during the electrographic seizure episodes
|
|
• chronic video electroencephalogram monitoring of freely moving mice show interictal spike discharges appearing initially over the temporal cortex that spread into a fully generalized seizure episode in the neocortex
• tonic or clonic behaviors are not seen during the electrographic seizure episodes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at 3 weeks, double homozygotes exhibit normal subcellular localization, developmental acquisition, and expression of large conductance voltage- and calcium-activated potassium (BK) channels relative to C57BL/6 wild-type mice
• at 8 weeks, double homozygotes display normal IHC function, as shown by normal ABR thresholds in response to click or pure tone stimuli (4-, 8-, 16-, and 32 kHz) relative to C57BL/6 wild-type mice
• in addition, double homozygotes display normal OHC function, as shown by normal DPOAE magnitudes over a range of frequencies relative to C57BL/6 wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/09/2024 MGI 6.23 |
|
|
|
||