immune system
• after weeks 2-8, mutants develop progressive splenomegaly
|
• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear
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• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control
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• mutants display hyperplasia of regional lymph nodes
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• at weeks 2 and 24, cervical lymph nodes are enlarged 2- and 10-fold respectively
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dermatitis
(
J:102470
)
• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions
|
hematopoietic system
• after weeks 2-8, mutants develop progressive splenomegaly
|
• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control
|
liver/biliary system
• at week 20, 50% of mutants have livers that are enlarged up to 2-fold
|
hearing/vestibular/ear
• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear
|
integument
dermal cyst
(
J:102470
)
dermatitis
(
J:102470
)
• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions
|
• mutants display progressive alopecia that is obvious by 6 weeks after Tamoxifen administration at 6 weeks of age
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• infiltrated cells and dilated blood vessels are present in the dermis; by week 24, there is heavy dermal infiltrate in mutant ears
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• at week 2, ear and dorsal skin biopsies show epidermal hyperplasia; at week 12. ears exhibit high epidermal hyperplasia
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scaly skin
(
J:102470
)
• at week 6-8, mice exhibit scaly skin on the trunk
|
skin lesions
(
J:102470
)
• at week 6-8, small lesions are macroscopically visible on the trunk
|
growth/size/body
dermal cyst
(
J:102470
)
• at week 20, 50% of mutants have livers that are enlarged up to 2-fold
|
• after weeks 2-8, mutants develop progressive splenomegaly
|