All Phenotypes Lama1<tm1.1Olf> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lama1^tm1.1Olf/Lama1^tm1.1Olf	involves: 129S2/SvPas	MGI:3611925
ht2	Lama1^nmf223/Lama1^tm1.1Olf	involves: 129S2/SvPas * C57BL/6J	MGI:4456179

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:102740 )

• death occurs between E6.5 and E7.5

embryo

increased embryonic tissue cell apoptosis ( J:102740 )

• increased TUNEL staining is seen in some embryos at E6.5 but not at E5.5; however, proliferation is similar to wild-type at E6.5

embryonic growth retardation ( J:102740 )

• at E6.5 significantly impaired growth is seen

abnormal ectoplacental cone morphology ( J:102740 )

abnormal parietal endoderm morphology ( J:102740 )

• the parietal endoderm is disorganized with fewer Krt1-19 positive cells

absent Reichert's membrane ( J:102740 )

• Reichert's membrane is absent and maternal blood cells are seen in the yolk sac

• however, embryonic basement membrane formation is normal

abnormal visceral endoderm morphology ( J:102740 )

• the visceral endoderm is disorganized with fewer Gata4 positive cells

cellular

increased embryonic tissue cell apoptosis ( J:102740 )

• increased TUNEL staining is seen in some embryos at E6.5 but not at E5.5; however, proliferation is similar to wild-type at E6.5

growth/size/body

embryonic growth retardation ( J:102740 )

• at E6.5 significantly impaired growth is seen

Allelic Composition	Lama1^nmf223/Lama1^tm1.1Olf
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama1^nmf223 mutation (1 available); any Lama1 mutation (186 available)
Lama1^tm1.1Olf mutation (0 available); any Lama1 mutation (186 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lama1^nmf223/Lama1^tm1.1Olf mice experience vitreal fibroplasia and vessel tortuosity

vision/eye

abnormal ocular fundus morphology ( J:160722 )

• ophthalmoscopy shows white spots, vitreal fibroplasia, and vessel tortuosity

abnormal retina morphology ( J:160722 )

abnormal retina vasculature morphology ( J:160722 )

vitreal fibroplasia ( J:160722 )

cardiovascular system

abnormal retina vasculature morphology ( J:160722 )

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