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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcb1btm1Bor
targeted mutation 1, Piet Borst
MGI:3610191
Summary 5 genotypes


Genotype
MGI:3622124
cx1
Allelic
Composition
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic
Background
FVB.129P2-Abcb1btm1Bor Abcb1atm1Bor Abcc2tm1Ahs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (84 available)
Abcc2tm1Ahs mutation (0 available); any Abcc2 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• bilary excretion of doxorubicin is reduced to about 2% normal




Genotype
MGI:5301411
cx2
Allelic
Composition
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-APPDutch)#Jckr/0
Genetic
Background
FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-APPDutch)#Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (84 available)
Tg(Thy1-APPDutch)#Jckr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice

homeostasis/metabolism
• mutants exhibit a similar level of cerebral amyloid angiopathy as in single Tg(Thy1-AppDutch)#Jckr transgenic mice




Genotype
MGI:5301408
cx3
Allelic
Composition
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background
FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (84 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

homeostasis/metabolism
• mutants exhibit an increase in the cortical load and size of amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice




Genotype
MGI:3611454
cx4
Allelic
Composition
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Genetic
Background
FVBTac.129P2-Abcb1btm1Bor Abcb1atm1Bor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increase in CD4+CD8+ intestinal intraepithelial lymphocytes
• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta
• proportion of CD8+ intestinal intraepithelial lymphocytes expressing CD8alpha beta markers rose from 5% in wild-type to 27% in mutants
• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta
• proliferative responses of isolated intestinal intraepithelial lymphocytes are higher in response to PMA stimulation and lower than wild-type in response to anti-CD28 stimulation
• PMA plus ionomycin stimulation results in increased IFN-gamma production by isolated intestinal intraepithelial lymphocytes compared to wild-type
• isolated intestinal intraepithelial lymphocytes produce increased levels of IL-2
• PMA plus ionomycin stimulation results in increased IL-2 production by intestinal intraepithelial lymphocytes compared with wild-type while anti-CD28 stimulation results in decreased IL-2 production compared to wild-type

homeostasis/metabolism
• lymph node T cells and to a lesser extent, intestinal intraepithelial lymphocytes, are impaired in extruding R-123, and efflux of R-123 is not inhibited by verapamil or reserpine as in controls (J:102640)
• bilary excretion of doxorubicin reduced by about 90% (J:107822)

hematopoietic system
• increase in CD4+CD8+ intestinal intraepithelial lymphocytes
• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta
• proportion of CD8+ intestinal intraepithelial lymphocytes expressing CD8alpha beta markers rose from 5% in wild-type to 27% in mutants
• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta
• proliferative responses of isolated intestinal intraepithelial lymphocytes are higher in response to PMA stimulation and lower than wild-type in response to anti-CD28 stimulation




Genotype
MGI:2386646
cx5
Allelic
Composition
Abcb1atm1Bor/Abcb1atm1Bor
Abcb1btm1Bor/Abcb1btm1Bor
Genetic
Background
involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1atm1Bor mutation (3 available); any Abcb1a mutation (93 available)
Abcb1btm1Bor mutation (2 available); any Abcb1b mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• altered pharmacokinetics of digoxin, with reduced elimination (and thus accumulation) of digoxin in the brain, adrenal glands, ovaries, and testis
• intestinal, but not biliary or urinary, excretion of digoxin is reduced in mice with a cannulated gallbladder
• intestinal, but not biliary or urinary, excretion of the anticancer drug paclitaxel is decreased compared to wild-type
• decreased rate of rhodamine efflux from hematopoietic progenitor cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory