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Allele Symbol Allele Name Allele ID |
Casp2tm1Vaux targeted mutation 1, David L Vaux MGI:3609949 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• thymocytes show normal levels and kinetics of apoptosis in response to anti-FAS antibody, dexamethasone, or gamma irradiation
• dorsal root ganglion neurons undergo apoptosis at a normal rate in response to withdrawel of nerve growth factor
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E14.5 a majority of embryos display brain over-growth similar to that found in Casp9tm1Flv homozygotes
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• thymocytes grown in wildtype hosts have only 10-20% of the DEVD-ase activity of wildtype or thymocytes deficient for only caspase 2
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| N |
• irradiated wildtype hosts reconstituted with E14.5 Casp2tm1Vaux Casp9tm1Flv double homozygous fetal liver develop normal thymocyte numbers and sub-populations with no thymocyte upregulation of caspases 1, 3, 6, 7, 8, or 9, normal B cell and T cell apoptosis in response to cytokine withdrawal, and normal T cell sensitivity to dexamethasone
• dexamethasone induced apoptosis of T cells (grown in wildtype hosts from E14.5 fetal liver) is blocked by caspase inhibitors but not by calpain and cathepsin inhibitors
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• thymocytes grown in wildtype hosts have only 10-20% of the DEVD-ase activity of wildtype or thymocytes deficient for only caspase 2
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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