About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Steap3tm1.1Mdf
targeted mutation 1.1, Mark D Fleming
MGI:3609928
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Steap3tm1.1Mdf/Steap3tm1.1Mdf involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J MGI:3609931
cx2
 		Del(1)1Brk/Steap3tm1.1Mdf involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J MGI:3609989


Genotype
MGI:3609931
hm1
Allelic
Composition		 Steap3tm1.1Mdf/Steap3tm1.1Mdf
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Steap3tm1.1Mdf mutation (1 available); any Steap3 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron homeostasis ( J:103440 )
• the transferrin-mediated iron uptake rate of reticulocyte-rich RBCs from 8 week old homozygous mutant mice is only about 30% that of such cells from wild-type mice
• upon reincubation with medium containing excess apo-transferrin, iron-laden erythrocytes from 8 week old homozygous mutant mice lose a significant proportion (17.8 +/- 3.3%) of the iron previously taken up by the cells
• at 8 weeks of age, the erythrocyte zinc-to-iron protoporphoryn IX ratio of homozygous mutant mice is approximately 3.5-fold that of wild-type mice
increased liver iron level ( J:103440 )
• the liver iron content of homozygous mutant mice is approximately 3-fold higher than that of wild-type mice

hematopoietic system
decreased hematocrit ( J:103440 )
• the hematocrit of 8 week old mice homozygous for the targeted mutation is about 75% that of wild-type mice
decreased hemoglobin content ( J:103440 )
• blood of 8 week old mice homozygous for the targeted mutation has a hemoglobin (g/dl) content about 64% that of blood from wild-type mice
decreased mean corpuscular hemoglobin ( J:103440 )
• red blood cells of 8 week old homozygous mutant mice contain only about 39% as much hemoglobin (pg) as RBCs of wild-type mice
decreased mean corpuscular hemoglobin concentration ( J:103440 )
• the hemoglobin concentration in red blood cells from 8 week old homozygous mutant mice is about 82% that of wild-type mice
decreased mean corpuscular volume ( J:103440 )
• 8 week old homozygous mutant mice have a mean RBC volume less than half that of wild-type mice
anisopoikilocytosis ( J:103440 )
• red blood cells of homozygous mutants vary in shape and size
thrombocytosis ( J:103440 )
• the platelet count of 8 week old homozygous mutant mice is 4 times that of wild-type mice
abnormal reticulocyte morphology ( J:103440 )
• reticulocytes of 8 week old homozygous mutant mice contain only half the cellular hemoglobin of those from wild-type mice
reticulocytosis ( J:103440 )
• in blood of 8 week old homozygous mutant mice, both the absolute number and the proportion of reticulocytes are significantly elevated over those in blood of mice with at least one wild-type allele

liver/biliary system
increased liver iron level ( J:103440 )
• the liver iron content of homozygous mutant mice is approximately 3-fold higher than that of wild-type mice




Genotype
MGI:3609989
cx2
Allelic
Composition		 Del(1)1Brk/Steap3tm1.1Mdf
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(1)1Brk mutation (1 available); any Del(1)1Brk mutation (1 available)
Steap3tm1.1Mdf mutation (1 available); any Steap3 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematocrit ( J:103440 )
• the hematocrit of 8 week old mice bearing the deletion in trans with the targeted allele is about 75% that of wild-type mice
decreased hemoglobin content ( J:103440 )
• blood of 8 week old complex heterozygous mice has a hemoglobin (g/dl) content about 65% that of blood from wild-type mice
decreased mean corpuscular hemoglobin ( J:103440 )
• red blood cells of 8 week old complex heterozygous mice contain only about 38% as much hemoglobin (pg) as RBCs of wild-type mice
decreased mean corpuscular hemoglobin concentration ( J:103440 )
• the hemoglobin concentration in red blood cells from 8 week old complex homozygotes is about 83% that of wild-type mice
decreased mean corpuscular volume ( J:103440 )
• 8 week old complex heterozygotes have a mean RBC volume approximately 45% that of wild-type mice
anisopoikilocytosis ( J:103440 )
• red blood cells of complex heterozygotes vary in shape and size
thrombocytosis ( J:103440 )
• the platelet count of 8 week old complex heterozygous mice is about 4.27 times that of wild-type mice
abnormal reticulocyte morphology ( J:103440 )
• reticulocytes of 8 week old complex heterozygous mice contain approximately half the cellular hemoglobin of those from wild-type mice
reticulocytosis ( J:103440 )
• in blood of 8 week old complex heterozygotes, both the absolute number and the proportion of reticulocytes are significantly elevated over those in blood of mice with at least one wild-type allele

homeostasis/metabolism
abnormal iron homeostasis ( J:103440 )
• the erythrocyte zinc-to-iron protoporphyrin IX ratio of 8 week old complex heterozygous mice is approximately 4.7-fold that of wild-type mice
increased liver iron level ( J:103440 )
• the liver iron content of complex heterozygotes is approximately 3-fold that of wild-type mice

liver/biliary system
increased liver iron level ( J:103440 )
• the liver iron content of complex heterozygotes is approximately 3-fold that of wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory