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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc8a1tm2Kdp
targeted mutation 2, Kenneth D Philipson
MGI:3609617
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc8a1tm2Kdp/Slc8a1tm2Kdp involves: 129S4/SvJae * Black Swiss MGI:3611571


Genotype
MGI:3611571
hm1
Allelic
Composition
Slc8a1tm2Kdp/Slc8a1tm2Kdp
Genetic
Background
involves: 129S4/SvJae * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc8a1tm2Kdp mutation (0 available); any Slc8a1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutant mice are embryonic lethal at 11.0 days postcoitum

cardiovascular system
• sarcoplasmic reticular membranes are diminished in mutant embryonic heart tubes at day 9.5 postcoitum
• mutant embryonic heart tubes at day 9.5 postcoitum display normal calcium transients under basal conditions, but are unable to maintain homeostasis when calcium fluxes are increased by various interventions (J:102710)
• mutant embryonic heart tubes at day 9.5 postcoitum display spontaneous calcium transients and contractile activity (J:103484)
• removal of extracellular sodium does not alter the calcium transients (J:103484)
• ouabain has no effect on mutant heart tube (J:103484)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory