Mouse Genome Informatics
cx1
    Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm

involves: 129 * 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mice exhibit decreased amyloid load compared with Apptm3.1Zhe Psen1tm1Mpm double homozygotes

other phenotype
• mice exhibit decreased amyloid load compared with Apptm3.1Zhe Psen1tm1Mpm double homozygotes


Mouse Genome Informatics
cx2
    Apptm1Ck/Apptm1Ck
Tg(PDGFB-PSEN1M146L)2Jhd/0

involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• in 1-year old animals, a relatively high number of cholinergic fiber aggregates in the cortex are observed in transgenic; at 20 months of age, a few such areas of densed cholinergic fiber aggregations are observed in other APP-targeted mice
• cholinergic fibers of large diameter are seen in layer 1 of the entorhinal cortex in mutant transgenic mice more prominently than in the other strains, but such fibers are present even in controls
• clusters of ballooned and spherical acetylcholine-immunoreactive terminals are observed in the periphery of compact amyloid plaques around the amyloid core in 12-month old animals, and numbers increase with age and plaque load
• amyloid plaques are detected in the brains of these mutant transgenic mice but not in App transgenic or App Tg(PDGFB-PSEN1M146L)2Jhd transgenic mutant mice up to 20 months of age

other phenotype
• amyloid plaques are detected in the brains of these mutant transgenic mice but not in App transgenic or App Tg(PDGFB-PSEN1M146L)2Jhd transgenic mutant mice up to 20 months of age