Phenotypes associated with this allele
Allelic Composition |
Ightm3Tim/Igh+
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Genetic Background |
involves: 129 * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Tim mutation
(0 available);
any
Igh mutation
(43 available)
|
|
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hematopoietic system
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• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
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• B cell compartment in mutant bone marrow was heterogeneous
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• B cell compartment in mutant spleen was heterogeneous
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immune system
|
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
|
|
• B cell compartment in mutant spleen was heterogeneous
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation
(1 available);
any
Igh-J mutation
(13 available)
Ightm3Tim mutation
(0 available);
any
Igh mutation
(43 available)
|
|
|
hematopoietic system
|
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
|
|
• B cell in mutants are reduced in the spleen, bone marrow and LNs
|
immune system
|
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
|
|
• B cell in mutants are reduced in the spleen, bone marrow and LNs
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation
(17 available);
any
Ighm mutation
(55 available)
Ightm3Tim mutation
(0 available);
any
Igh mutation
(43 available)
|
|
|
hematopoietic system
|
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
|
|
• B cell in mutants are reduced in the spleen, bone marrow and LNs
|
immune system
|
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
|
|
• B cell in mutants are reduced in the spleen, bone marrow and LNs
|