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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(F2RL1)1Mslb
transgene insertion 1, Mary Stevens
MGI:3609028
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(F2RL1)1Mslb/0 involves: FVB/NCrl MGI:3784838


Genotype
MGI:3784838
tg1
Allelic
Composition
Tg(F2RL1)1Mslb/0
Genetic
Background
involves: FVB/NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(F2RL1)1Mslb mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following sensitization with ovalbumin and exposure to ovalbumin, mice exhibit an 88% increase in cellular inflammatory infiltrate in bronchoalveolar lavage (specifically, total and eosinophil) compared to in similarly treated wild-type mice at 24 hours but not 72 hours post-exposure
• however, cellular composition of the inflammatory infiltrate is normal and IgE levels are normal
• ovalbumin-induced airway hypersensitivity to methacholine is greater than in similarly treated wild-type mice (57% increase at 20 ug/ml and 52% at 40 ug/ml methacholine)

respiratory system
• ovalbumin-induced airway hypersensitivity to methacholine is greater than in similarly treated wild-type mice (57% increase at 20 ug/ml and 52% at 40 ug/ml methacholine)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory