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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Psen1tm1Dgf
targeted mutation 1, Dorothy G Flood
MGI:3608968
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Psen1tm1Dgf/Psen1tm1Dgf involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:4413474
cx2
Psen1tm1Dgf/Psen1tm1Dgf
Tg(APPSWE)2576Kha/?
involves: 129 * C57BL/6 * CD-1 * SJL MGI:3611211
cx3
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3611210
cx4
Psen1tm1Dgf/Psen1+
Tg(APPSWE)2576Kha/0
involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL MGI:2652383


Genotype
MGI:4413474
hm1
Allelic
Composition
Psen1tm1Dgf/Psen1tm1Dgf
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Dgf mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• basal level of cortical neuron apoptosis in response to three different apoptogenic agents is similar to controls




Genotype
MGI:3611211
cx2
Allelic
Composition
Psen1tm1Dgf/Psen1tm1Dgf
Tg(APPSWE)2576Kha/?
Genetic
Background
involves: 129 * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Dgf mutation (0 available); any Psen1 mutation (28 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• accelerated onset of amyloid deposition in a gene-dosage dependent manner
• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

homeostasis/metabolism
• accelerated onset of amyloid deposition in a gene-dosage dependent manner
• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:102425




Genotype
MGI:3611210
cx3
Allelic
Composition
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1.1Cep mutation (0 available); any App mutation (22 available)
Psen1tm1Dgf mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

homeostasis/metabolism
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:102425




Genotype
MGI:2652383
cx4
Allelic
Composition
Psen1tm1Dgf/Psen1+
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Dgf mutation (0 available); any Psen1 mutation (28 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice
• mutants exhibit enhanced reactive gliosis compared to single Tg(APPSWE)2576Kha mice

homeostasis/metabolism
• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice





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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory