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hm1
|
Psen1tm1Dgf/Psen1tm1Dgf
involves: 129S1/Sv * 129X1/SvJ * CD-1 |
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| N |
• basal level of cortical neuron apoptosis in response to three different apoptogenic agents is similar to controls
(J:66147)
|
|
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cx2
|
Psen1tm1Dgf/Psen1tm1Dgf Tg(APPSWE)2576Kha/? involves: 129 * C57BL/6 * CD-1 * SJL |
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• accelerated onset of amyloid deposition in a gene-dosage dependent manner
• amyloid-beta deposition was widely distributed throughout the brain and spinal cord
|
|
• accelerated onset of amyloid deposition in a gene-dosage dependent manner
• amyloid-beta deposition was widely distributed throughout the brain and spinal cord
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Alzheimer Disease; AD | 104300 | J:102425 | |
|
|
cx3
|
Apptm1.1Cep/Apptm1.1Cep Psen1tm1Dgf/Psen1tm1Dgf involves: 129S1/Sv * 129X1/SvJ * CD-1 |
|
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• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition
(J:66147)
• amyloid-beta deposition beginning at 6 months of age
(J:102425)
• deposition increased linearly over time
(J:102425)
|
|
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition
(J:66147)
• amyloid-beta deposition beginning at 6 months of age
(J:102425)
• deposition increased linearly over time
(J:102425)
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Alzheimer Disease; AD | 104300 | J:102425 | |
|
|
cx4
|
Psen1tm1Dgf/Psen1+ Tg(APPSWE)2576Kha/0 involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL |
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• mutants exhibit enhanced reactive gliosis compared to single Tg(APPSWE)2576Kha mice
|
|
• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice
|
|
• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice
|