Mouse Genome Informatics
hm1
    Psen1tm1Dgf/Psen1tm1Dgf
involves: 129S1/Sv * 129X1/SvJ * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• basal level of cortical neuron apoptosis in response to three different apoptogenic agents is similar to controls (J:66147)


Mouse Genome Informatics
cx2
    Psen1tm1Dgf/Psen1tm1Dgf
Tg(APPSWE)2576Kha/?

involves: 129 * C57BL/6 * CD-1 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• accelerated onset of amyloid deposition in a gene-dosage dependent manner
• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

homeostasis/metabolism
• accelerated onset of amyloid deposition in a gene-dosage dependent manner
• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:102425


Mouse Genome Informatics
cx3
    Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf

involves: 129S1/Sv * 129X1/SvJ * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

homeostasis/metabolism
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:102425


Mouse Genome Informatics
cx4
    Psen1tm1Dgf/Psen1+
Tg(APPSWE)2576Kha/0

involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice
• mutants exhibit enhanced reactive gliosis compared to single Tg(APPSWE)2576Kha mice

homeostasis/metabolism
• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice