All Phenotypes Psen1<tm1Dgf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Psen1^tm1Dgf
targeted mutation 1, Dorothy G Flood
MGI:3608968

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psen1^tm1Dgf/Psen1^tm1Dgf	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:4413474
cx2	Psen1^tm1Dgf/Psen1^tm1Dgf Tg(APPSWE)2576Kha/?	involves: 129 * C57BL/6 * CD-1 * SJL	MGI:3611211
cx3	App^tm1.1Cep/App^tm1.1Cep Psen1^tm1Dgf/Psen1^tm1Dgf	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3611210
cx4	Psen1^tm1Dgf/Psen1⁺ Tg(APPSWE)2576Kha/0	involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL	MGI:2652383

Allelic Composition	Psen1^tm1Dgf/Psen1^tm1Dgf
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1Dgf mutation (0 available); any Psen1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:66147 )

N	• basal level of cortical neuron apoptosis in response to three different apoptogenic agents is similar to controls

Allelic Composition	Psen1^tm1Dgf/Psen1^tm1Dgf Tg(APPSWE)2576Kha/?
Genetic Background	involves: 129 * C57BL/6 * CD-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1Dgf mutation (0 available); any Psen1 mutation (46 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:102425 )

• accelerated onset of amyloid deposition in a gene-dosage dependent manner

• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

homeostasis/metabolism

amyloid beta deposits ( J:102425 )

• accelerated onset of amyloid deposition in a gene-dosage dependent manner

• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:102425

Allelic Composition	App^tm1.1Cep/App^tm1.1Cep Psen1^tm1Dgf/Psen1^tm1Dgf
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1.1Cep mutation (0 available); any App mutation (89 available)
Psen1^tm1Dgf mutation (0 available); any Psen1 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:66147 , J:102425 )

• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)

• amyloid-beta deposition beginning at 6 months of age (J:102425)

• deposition increased linearly over time (J:102425)

homeostasis/metabolism

amyloid beta deposits ( J:66147 , J:102425 )

• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)

• amyloid-beta deposition beginning at 6 months of age (J:102425)

• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:102425

Allelic Composition	Psen1^tm1Dgf/Psen1⁺ Tg(APPSWE)2576Kha/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1Dgf mutation (0 available); any Psen1 mutation (46 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:66147 )

• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice

gliosis ( J:66147 )

• mutants exhibit enhanced reactive gliosis compared to single Tg(APPSWE)2576Kha mice

homeostasis/metabolism

amyloid beta deposits ( J:66147 )

• accelerated onset of amyloid plaque deposition and increased amyloidogenic processing of APP compared to single Tg(APPSWE)2576Kha mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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