About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgb8tm2Lfr
targeted mutation 2, Louis F Reichardt
MGI:3608910
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Tek-cre)1Rwng/0 		involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:3609118
cn2
 		Itgb8tm1Lfr/Itgb8tm2Lfr
Neurod6tm1(cre)Kan/Neurod6+ 		involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3609115
cn3
 		Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Nes-cre)1Kln/0 		involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3609116
cn4
 		Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Nes-cre)1Wmz/0 		involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3609117


Genotype
MGI:3609118
cn1
Allelic
Composition		 Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Tek-cre)1Rwng/0
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb8tm1Lfr mutation (1 available); any Itgb8 mutation (44 available)
Itgb8tm2Lfr mutation (1 available); any Itgb8 mutation (44 available)
Tg(Tek-cre)1Rwng mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:102190 )
• no hemorrhages or other defects are seen in the brain and a normal vascular plexus develops in the brain




Genotype
MGI:3609115
cn2
Allelic
Composition		 Itgb8tm1Lfr/Itgb8tm2Lfr
Neurod6tm1(cre)Kan/Neurod6+
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb8tm1Lfr mutation (1 available); any Itgb8 mutation (44 available)
Itgb8tm2Lfr mutation (1 available); any Itgb8 mutation (44 available)
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:102190 )
• no hemorrhages or other defects are seen in the brain




Genotype
MGI:3609116
cn3
Allelic
Composition		 Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb8tm1Lfr mutation (1 available); any Itgb8 mutation (44 available)
Itgb8tm2Lfr mutation (1 available); any Itgb8 mutation (44 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:102190 )
• blood vessels in the brain do not run parallel to the astroglia
abnormal vascular endothelial cell morphology ( J:102190 )
• vessels in the brain develop large irregular endothelial cell clusters
intracranial hemorrhage ( J:102190 )
• at P0 hemorrhages are seen in the dorsal cortex, thalamus, and in the ganglionic eminence near the deep mesencephalic nucleus; however hemorrhages are not seen in adult mutants and no cortical lamination defects are seen in adults
• hemorrhaging is less severe than in mice homozygous for Itgb8tm1Lfr

nervous system
intracranial hemorrhage ( J:102190 )
• at P0 hemorrhages are seen in the dorsal cortex, thalamus, and in the ganglionic eminence near the deep mesencephalic nucleus; however hemorrhages are not seen in adult mutants and no cortical lamination defects are seen in adults
• hemorrhaging is less severe than in mice homozygous for Itgb8tm1Lfr
abnormal astrocyte morphology ( J:102190 )
• at E14.5 radial glia near the ganglionic eminence (where hemorrhaging could be seen) are disorganized but those in the developing cortex (where hemorrhages are not yet present) appear normal
• at P0 astroglia appear disorganized and lack the normal parallel organization
• blood vessels in the brain do not run parallel to the astoglia




Genotype
MGI:3609117
cn4
Allelic
Composition		 Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Nes-cre)1Wmz/0
Genetic
Background		 involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb8tm1Lfr mutation (1 available); any Itgb8 mutation (44 available)
Itgb8tm2Lfr mutation (1 available); any Itgb8 mutation (44 available)
Tg(Nes-cre)1Wmz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
intracranial hemorrhage ( J:102190 )
• hemorrhaging is similar to mutants crossed to Tg(Nes-cre)1Kln and less severe than in mice homozygous for Itgb8tm1Lfr

nervous system
intracranial hemorrhage ( J:102190 )
• hemorrhaging is similar to mutants crossed to Tg(Nes-cre)1Kln and less severe than in mice homozygous for Itgb8tm1Lfr




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory