Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm1Zm mutation
(1 available);
any
Cx3cr1 mutation
(45 available)
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vision/eye
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• subretinal microglial cells accumulate with age in the retina unlike in wild-type mice
• however, dark raised mice exhibit reduced numbers of subretinal microglial cells in the retina
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• the retinal photoreceptor layer is thin at 2 months and degenerated at 4 months of age
• however, dark raised mice do not exhibit thinning or degeneration
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• mice exhibit degeneration of the outer retina
• however, dark raised mice do not exhibit degeneration
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm1Zm mutation
(1 available);
any
Cx3cr1 mutation
(45 available)
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vision/eye
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• following laser injury, choroid neovascularization is twice as much as in similarly treated wild-type mice
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• subretinal microglial cells accumulate with age in the retina unlike in wild-type mice
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• at 12 months, mice exhibit a 30% reduction in the thickness of the retinal outer nuclear layer compared to in wild-type mice
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• at 18 months, the thickness of the retinal photoreceptor cell layer is reduced to 40% of wild-type
• following laser injury, mice exhibit increased degeneration compared to untreated homozygotes or similarly treated wild-type mice
• however, mice do not exhibit increased degeneration following laser injuries at distances of 300 and 400 um from laser impact
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• mice exhibit an accumulation of yellow, lipid-bloated subretinal microglial cells in the deep layer of the retina with age that is not observed in wild-type mice
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cardiovascular system
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• following laser injury, choroid neovascularization is twice as much as in similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm1Zm mutation
(1 available);
any
Cx3cr1 mutation
(45 available)
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hematopoietic system
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• absent splenocyte chemotaxis in response to CX3CL1; however induction of T cell cytokine production by concanavalin A is similar to wild-type
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immune system
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• absent splenocyte chemotaxis in response to CX3CL1; however induction of T cell cytokine production by concanavalin A is similar to wild-type
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cardiovascular system
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• lesion area in the aorta and aortic sinus is decreased by about 50% compared to mice homozygous for the Apoe allele only; however the accumulation of smooth muscle cells and collagen within the plaque is similar to wild-type
• a 50% reduction is seen in the aortic sinus area containing monocyte-macrophage markers
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cardiovascular system
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• lesion area in the thoracic aorta is decreased by about 50% compared to mice homozygous for the Apoe allele only
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vision/eye
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• beginning as early as 12 weeks of age,15% of mice exhibit neovascularization of the choroid unlike in wild-type mice
• choroidal neovascular vessels that penetrate Bruch membrane and enter the outer retinal layers are surrounded by hyperplastic retinal pigmented epithelium cells or atrophic retinal pigmented epithelium areas
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• microglial infiltrates are observed in retinal lesions
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• severity increases with age
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• unlike in wild-type mice, vacuolation of the retinal pigmented epithelium (RPE) is observed
• mice exhibit a reduction in melanosomes and an increase in lipofuscin in the RPE unlike in wild-type mice
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• unlike in wild-type mice, local hypopigmentation of the retina is observed
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• in some areas with severity increasing with age
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• by 6 to 9 weeks, mice exhibit drusen-like lesions with heterogeneous, round or domed-shaped, soft-bordered yellowish deposits within the subretina not observed in wild-type mice
• retinal depositions enlarge or flatten and become confluent with age
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• beginning at 8 weeks of age, mice exhibit focal thickening in the Bruch membrane compared to wild-type mice
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reproductive system
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• average litter size is half of wild-type
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nervous system
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• severity increases with age
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pigmentation
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• 20% of mice exhibit patchy skin depigmentation on the face and upper extremities
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• unlike in wild-type mice, vacuolation of the retinal pigmented epithelium (RPE) is observed
• mice exhibit a reduction in melanosomes and an increase in lipofuscin in the RPE unlike in wild-type mice
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• unlike in wild-type mice, local hypopigmentation of the retina is observed
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• in some areas with severity increasing with age
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cardiovascular system
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• beginning as early as 12 weeks of age,15% of mice exhibit neovascularization of the choroid unlike in wild-type mice
• choroidal neovascular vessels that penetrate Bruch membrane and enter the outer retinal layers are surrounded by hyperplastic retinal pigmented epithelium cells or atrophic retinal pigmented epithelium areas
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integument
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• 20% of mice exhibit patchy skin depigmentation on the face and upper extremities
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Analysis Tools