Analysis Tools
cellular
| N |
• no obvious microtubule abnormalities in MEFs in a wound healing assay
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Allele Symbol Allele Name Allele ID |
Clip1tm1Gal targeted mutation 1, Niels Galjart MGI:3607145 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no obvious microtubule abnormalities in MEFs in a wound healing assay
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mutant sperm exhibit an abnormal morphology
• however, sperm numbers and motility are similar to wild-type
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• 20% of mutant sperm exhibit combined head and tail defects
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• 100% of mutant sperm display severe head abnormalities
• 20% of mutant sperm exhibit combined head and tail defects
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• in step 8-9 spermatids developing manchettes have abnormal and ectopic microtubule formations
• however, the few cross-bridges between microtubules are similar to wild-type in size
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• homozygous males produce almost no offspring
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• all mutant sperm exhibit an abnormal morphology
• however, sperm numbers and motility are similar to wild-type
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• 20% of mutant sperm exhibit combined head and tail defects
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• 100% of mutant sperm display severe head abnormalities
• 20% of mutant sperm exhibit combined head and tail defects
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• in step 8-9 spermatids developing manchettes have abnormal and ectopic microtubule formations
• however, the few cross-bridges between microtubules are similar to wild-type in size
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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