Phenotypes associated with this allele

• Allele Symbol: Nr0b2^tm1Rus
• Allele Name: targeted mutation 1, David W Russell
• Allele ID: MGI:3607116
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr0b2^tm1Rus/Nr0b2^tm1Rus	involves: 129P2/OlaHsd * C57BL/6	MGI:3607147

Genotype
MGI:3607147

hm1

• Allelic Composition: Nr0b2^tm1Rus/Nr0b2^tm1Rus
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating alanine transaminase level ( J:102129 )

• plasma levels of alanine aminotransferase greatly increased on diets supplemented with bile salts

increased circulating aspartate transaminase level ( J:102129 )

• plasma levels of aspartate aminotransferase greatly increased on diets supplemented with bile salts

abnormal lipid homeostasis ( J:102129 )

• excretion of neural sterols significantly decreased

increased intestinal cholesterol absorption ( J:102129 )

• 22% increased absorption by the gut

• plasma lipid levels remain normal

abnormal bile salt homeostasis ( J:102129 )

• bile acid pool 32% larger than normal

abnormal bile salt level ( J:102129 )

• elevated cholic acid and deoxycholic acid

• decreased beta-muricholate

• 33% increase in fecal bile acid excretion

liver/biliary system

abnormal liver physiology ( J:102129 )

• liver enzymes in circulation indicative of toxic effect of added bile salts in the diet

digestive/alimentary system

increased intestinal cholesterol absorption ( J:102129 )

• 22% increased absorption by the gut

• plasma lipid levels remain normal