Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Ipch mutation
(0 available);
any
P2rx7 mutation
(52 available)
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behavior/neurological
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• in mutant mice development of both thermal and mechanical hypersensitivity was completely absent following nerve ligation
• nociceptive processing in the absence of any neuropathic or inflammatory insult was normal
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immune system
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• mutant mice failed to develop significant hypersensitivity at any time after Freund's Complete Adjuvant ?induced inflammation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Ipch mutation
(0 available);
any
P2rx7 mutation
(52 available)
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immune system
N |
• radical-mediated bacterial killing in macrophages is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Ipch mutation
(0 available);
any
P2rx7 mutation
(52 available)
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immune system
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• unlike wild-type cells, macrophages are not killed by ATP stimulation over a 16-hour period
• bone marrow-derived macrophages infected with bacille Calmette-Guerin and stimulated with ATP exhibit decreased killing of the mycobacteria compared with similarly treated wild-type cells
• macrophages fail to form coalesced and acidified multibacillary vacuoles unlike in similarly infected and stimulated wild-type cells
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hematopoietic system
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• unlike wild-type cells, macrophages are not killed by ATP stimulation over a 16-hour period
• bone marrow-derived macrophages infected with bacille Calmette-Guerin and stimulated with ATP exhibit decreased killing of the mycobacteria compared with similarly treated wild-type cells
• macrophages fail to form coalesced and acidified multibacillary vacuoles unlike in similarly infected and stimulated wild-type cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx7tm1Ipch mutation
(0 available);
any
P2rx7 mutation
(52 available)
|
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cardiovascular system
N |
• mice exhibit normal response to carotid ligation
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