Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd2bp2tm1.1Tbh mutation
(0 available);
any
Cd2bp2 mutation
(26 available)
Tg(T-cre)1Lwd mutation
(1 available)
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mortality/aging
embryo
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• delayed vasculatization
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cardiovascular system
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• delayed vasculatization
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cardiovascular system
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• 3 of 14 mice exhibit defective cardiac septation and 1 of 14 mice exhibit abnormal left-right patterning
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• both the aorta and the pulmonary trunk arise from the right ventricle
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• indicated by bilateral systemic venous sinuses and a common atrium created by complete absence of the primary atrial septum
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• common atrium created by complete absence of the primary atrial septum
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respiratory system
endocrine/exocrine glands
growth/size/body
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• indicated by bilateral systemic venous sinuses and a common atrium created by complete absence of the primary atrial septum
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation
(1 available);
any
Fgf8 mutation
(18 available)
Fgf8tm1.4Mrt mutation
(0 available);
any
Fgf8 mutation
(18 available)
Tg(T-cre)1Lwd mutation
(1 available)
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mortality/aging
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• mutants die shortly after birth
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renal/urinary system
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• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia
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• no glomeruli are present at any stage of kidney development
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• at E14.5 mutant kidneys show only condensation and renal vesicle formation and not tubulogenesis or glomerulogenesis that are seen in wild-type mice
• at E16.5 evidence of cap formation is mostly missing and few vesicles remain in the mutant kidneys and those remaining vesicles do not show signs of tubulogenesis
• at E18.5 the hypocellular kidney is largely devoid of nephron epithelia
• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia
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• at E18.5 the few remaining ureteric bud radii fail to bifurcate in the cortical nephrogenic region; however, somite formation, tendon progenitor populations fro E10.5 - E14.5, and limb bud induction are normal
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• at E14.5 ureteric bud branching is dramatically reduced
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limbs/digits/tail
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• most mutants lack at least one hindlimb digit; however, limb bud induction is normal
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skeleton
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N |
• no defects are seen in skeletal development including rib formation
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cellular
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• apoptosis is increased at E14.5 most prominently in the cortical mesenchyme and at E16.5 in the primitive epithelia
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Ctnnb1tm2Kem mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Tg(T-cre)1Lwd mutation
(1 available)
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embryo
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• severely truncated at E8.5
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• at E8.5, somites are disorganized
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(T-cre)1Lwd mutation
(1 available)
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skeleton
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• 33% of mutants show fusion of ribs in the thoracic region
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• neonates show vertebral malformations with a higher penetrance at the cervical level than at thoracic and lumber regions
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• reduction in the number of thoracic vertebrae (12 instead of 13)
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• absence of the tuberculum anterior on C6
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• some mutants only have five lumbar vertebrae instead of six
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• cervical regions show malformed neural arches
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• neonates show vertebral fusions with a higher penetrance at the cervical level than at thoracic and lumber regions
• cervical vertebra 1 and associated anterior arch of the atlas are fused to the basioccipital bone
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• neonates show the presence of a high number of homeotic transformations
• C2/C3 are anteriorly transformed
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• cervical regions show anterior homeotic transformations
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation
(0 available);
any
Etv4 mutation
(40 available)
Etv5tm1.1Xsun mutation
(2 available);
any
Etv5 mutation
(270 available)
Etv5tm1.2Xsun mutation
(0 available);
any
Etv5 mutation
(270 available)
Tg(T-cre)1Lwd mutation
(1 available)
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mortality/aging
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• mice die shortly after birth due to internal organ defects
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limbs/digits/tail
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• limb buds exhibit reduced cell death compared to in wild-type mice
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• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice
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• mice exhibit preaxial polydactyly in the hindlimbs with one or two extra digits the majority of which are triphalangeal
• however, forelimbs are normal
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embryo
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• limb buds exhibit reduced cell death compared to in wild-type mice
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skeleton
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• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation
(0 available);
any
Etv4 mutation
(40 available)
Etv5tm1.1Xsun mutation
(2 available);
any
Etv5 mutation
(270 available)
Etv5tm1.2Xsun mutation
(0 available);
any
Etv5 mutation
(270 available)
Tg(T-cre)1Lwd mutation
(1 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm1.1Mku mutation
(0 available);
any
Nodal mutation
(41 available)
Nodaltm2Mku mutation
(1 available);
any
Nodal mutation
(41 available)
Tg(T-cre)1Lwd mutation
(1 available)
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cardiovascular system
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• the direction of looping is reversed in about half of the embryos at E8.5 - E9.5
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embryo
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• expression analysis indicates complete loss of asymmetric signals in the lateral plate mesoderm
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growth/size/body
hematopoietic system
immune system
respiratory system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(T-cre)1Lwd mutation
(1 available)
Zic3tm2.1Jwb mutation
(1 available);
any
Zic3 mutation
(37 available)
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mortality/aging
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• despite normal numbers at E9.5, fewer than expected mice at E15.5 and weaning
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cardiovascular system
limbs/digits/tail
growth/size/body
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• laterality defects in 4 of 18 mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpl10atm1c(EUCOMM)Hmgu mutation
(0 available);
any
Rpl10a mutation
(50 available)
Tg(T-cre)1Lwd mutation
(1 available)
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embryo
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N |
• mice exhibit normal posterior trunk
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.2Cxd mutation
(0 available);
any
Fgfr1 mutation
(221 available)
Tg(T-cre)1Lwd mutation
(1 available)
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mortality/aging
embryo
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• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
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• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
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• at E9.5 the open neural plate is expanded
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• somite size is irregular
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limbs/digits/tail
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• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
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• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
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• the forelimb autopod has only 3 digits 1 with 3 phalanges and 2 with 2 phalanges
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• at E17.5, the stylopod is shortened by about 15%
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• at E17.5, the zeugopod is reduced by about 12% and often fused at the distal end
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• the hindlimb is more severely affected than the forelimb
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nervous system
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• at E9.5 the open neural plate is expanded
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skeleton
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• at E17.5 the initial cartilage condensations in the forelimb are reduced in number and size
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.1Cxd mutation
(0 available);
any
Fgfr1 mutation
(221 available)
Fgfr1tm3.2Cxd mutation
(0 available);
any
Fgfr1 mutation
(221 available)
Tg(T-cre)1Lwd mutation
(1 available)
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mortality/aging
embryo
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• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
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• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
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• at E9.5 the open neural plate is expanded
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• somite size is irregular
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limbs/digits/tail
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• at E10.0, in the forelimb bud the apical ectodermal ridge is wider along the dorsal ventral axis and at E10.5 shorter along the anterior posterior axis
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• at E10 the forelimb bud is shorter along the proximal distal axis, wider along the anterior posterior axis and thicker on the dorsal ventral axis and this differences are increased at E10.5
• at E11.5 individual digit condensations cannot be identified
• the number of cells in the forelimb bud is increased 65% and 31% at E10.0 and E10.5, respectively, but decreased by 26% at E11.5 and cell death is increased starting at E10.5 although still confined to the normal cell death domain
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• the forelimb autopod has only 3 digits 1 with 3 phalanges and 2 with 2 phalanges
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• at E17.5, the stylopod is shortened by about 15%
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• at E17.5, the zeugopod is reduced by about 12% and often fused at the distal end
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• the hindlimb is more severely affected than the forelimb
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nervous system
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• at E9.5 the open neural plate is expanded
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skeleton
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• at E17.5 the initial cartilage condensations in the forelimb are reduced in number and size
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hearing/vestibular/ear
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N |
• normal vestibular and cochlear morphologies
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Eomestm1Rob mutation
(0 available);
any
Eomes mutation
(41 available)
Tg(T-cre)1Lwd mutation
(1 available)
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embryo
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N |
• Mendelian numbers of conditionally null embryos are recovered around E6.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(T-cre)1Lwd mutation
(1 available)
Zic3tm1.1Smwa mutation
(0 available);
any
Zic3 mutation
(37 available)
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embryo
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• similar to germ line null mice
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cardiovascular system
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• defects in looping similar to those in germ line null mice are seen at E10.5 and E13.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fan mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(T-cre)1Lwd mutation
(1 available)
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Cervical vertebrae fusions in Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sor+ Tg(T-cre)1Lwd/0 mice
skeleton
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• seen in approximately 40% of adults
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fan mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(T-cre)1Lwd mutation
(1 available)
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Skeletal defects in Gt(ROSA)26Sortm1Fan/Gt(ROSA)26Sortm1Fan Tg(T-cre)1Lwd/0 mice
mortality/aging
embryo
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• at E8.5 somite lose their compact epithelial morphology, instead cells display a scattered pattern
• poorly defined boundaries are seen along the body axis at E8.75
• lack well separated epithelia at E9.5
• at E11.5 long stretches of mesenchymal patches that fail to segregate into repeated intervals are seen
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nervous system
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• axon bundles are not properly spaced
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skeleton
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• conspicuously defective along the cervical, trunk, and lumbar regions and to a lesser extent in the tail
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• loss of intervertebral disks
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• fusions of the neural arches and vertebral bodies
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limbs/digits/tail
behavior/neurological
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• straightened posture in neonates
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Analysis Tools