All Phenotypes Adamts13<tm1Dgi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts13^tm1Dgi/Adamts13^tm1Dgi	B6.129X1-Adamts13^tm1Dgi	MGI:4834629
hm2	Adamts13^tm1Dgi/Adamts13^tm1Dgi	involves: 129X1/SvJ * C57BL/6J	MGI:3606955
hm3	Adamts13^tm1Dgi/Adamts13^tm1Dgi	involves: 129X1/SvJ * C57BL/6J * CASA/Rk	MGI:3606957
cx4	Adamts13^tm1Dgi/Adamts13^tm1Dgi Vwf^tm1Wgr/Vwf^tm1Wgr	B6.129-Adamts13^tm1Dgi Vwf^tm1Wgr	MGI:4834630
cx5	Adamts13^tm1Dgi/Adamts13^tm1Dgi Vwf^tm1Wgr/Vwf^tm1Wgr	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CASA/Rk	MGI:4834624

Allelic Composition	Adamts13^tm1Dgi/Adamts13^tm1Dgi
Genetic Background	B6.129X1-Adamts13^tm1Dgi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts13^tm1Dgi mutation (1 available); any Adamts13 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:133469 )

• following FeCl3 injury, mice exhibit a reduced time to clot formation and vessel occlusion compared with similarly treated wild-type mice

Allelic Composition	Adamts13^tm1Dgi/Adamts13^tm1Dgi
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts13^tm1Dgi mutation (1 available); any Adamts13 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:101752 )

• Background Sensitivity: exhibit normal development, fertility, survival, blood smears and a similar response to shiga toxin as wildtype, even though von Willebrand Factor (vWF)-cleaving activity is lost, unlike on a background that contains CASA/Rk

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:101752 )

N	• Background Sensitivity: associated phenotypes appear after crossing to CASA/Rk mice

premature death ( J:101752 )

• exhibit a significant decrease in survival than wildtype

hematopoietic system

hematopoietic system phenotype ( J:101752 )

N	• Background Sensitivity: associated phenotypes appear after crossing to CASA/Rk mice

abnormal erythrocyte morphology ( J:101752 )

• peripheral blood smear shows schistocytes and fragmented red blood cells

thrombocytopenia ( J:101752 )

• decrease in average platelet count in peripheral blood

abnormal platelet physiology ( J:101752 )

• platelets show significantly prolonged adhesion to endothelial cells

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:101752 )

N	• Background Sensitivity: associated phenotypes appear after crossing to CASA/Rk mice

abnormal platelet physiology ( J:101752 )

• platelets show significantly prolonged adhesion to endothelial cells

increased circulating von Willebrand factor level ( J:101752 )

• 40-50% increase in mean plasma von Willebrand Factor (vWF) level

• appearance of ultra-long vWF similar to the pattern observed in human thrombotic thrombocytopenic purpura (TPP)

abnormal thrombosis ( J:101752 )

• exhibit widespread vWF-rich and fibrin-poor hyaline thrombi in the small vessels of multiple organs

immune system

immune system phenotype ( J:101752 )

N	• Background Sensitivity: associated phenotypes appear after crossing to CASA/Rk mice

increased susceptibility to bacterial infection ( J:101752 )

• shiga toxin injection causes increased mortality, thrombocytopenia, microangiopathic hemolytic anemia and widespread vWF-rich and fibrin-poor hyaline thrombi in the small vessels of multiple organs and results in a syndrome closely resembling human thrombotic thrombocytopenic purpura

Allelic Composition	Adamts13^tm1Dgi/Adamts13^tm1Dgi Vwf^tm1Wgr/Vwf^tm1Wgr
Genetic Background	B6.129-Adamts13^tm1Dgi Vwf^tm1Wgr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts13^tm1Dgi mutation (1 available); any Adamts13 mutation (69 available)
Vwf^tm1Wgr mutation (1 available); any Vwf mutation (139 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:133469 )

N	• mice exhibit the same LPS-induced thrombocytopenia as in Adamts13^tm1Dgi or Vwf^tm1Wgr homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:133469 )

N	• mice exhibit the same LPS-induced thrombocytopenia as in Adamts13^tm1Dgi or Vwf^tm1Wgr homozygotes

decreased susceptibility to induced thrombosis ( J:133469 )

• following FeCl3 injury, mice exhibit an increased time to clot formation and fail to completely occlude vessels unlike similarly treated wild-type mice

Allelic Composition	Adamts13^tm1Dgi/Adamts13^tm1Dgi Vwf^tm1Wgr/Vwf^tm1Wgr
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * CASA/Rk

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:133469 )

• in shigatoxin (Stx)-treated mice

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:133469 )

• in shigatoxin (Stx)-treated mice

decreased physiological sensitivity to xenobiotic ( J:133469 )

• shigatoxin (Stx)-treated mice exhibit less severe thrombocytopenia and reduced mortality compared with similarly treated Adamts13^tm1Dgi homozygotes

hematopoietic system

abnormal platelet morphology ( J:133469 )

• shigatoxin (Stx)-treated mice exhibit less severe thrombocytopenia and reduced mortality compared with similarly treated Adamts13^tm1Dgi homozygotes

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