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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nectin1tm1Ytk
targeted mutation 1, Yoshimi Takai
MGI:3605480
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nectin1tm1Ytk/Nectin1tm1Ytk either: (involves: 129X1/SvJ * C57BL * DBA) or (involves: 129X1/SvJ * BALB/cA * C57BL * DBA) MGI:3607448
hm2
Nectin1tm1Ytk/Nectin1tm1Ytk involves: 129X1/SvJ * C57BL/6 MGI:4838217
cx3
Nectin1tm1Ytk/Nectin1tm1Ytk
Nectin3tm1Ytk/Nectin3tm1Ytk
involves: 129X1/SvJ * C57BL/6 MGI:4838219
cx4
Nectin1tm1Ytk/Nectin1+
Nectin3tm1Ytk/Nectin3tm1Ytk
involves: 129X1/SvJ * C57BL/6 MGI:4838220
cx5
Nectin1tm1Ytk/Nectin1tm1Ytk
Nectin3tm1Ytk/Nectin3+
involves: 129X1/SvJ * C57BL/6 MGI:4838221


Genotype
MGI:3607448
hm1
Allelic
Composition
Nectin1tm1Ytk/Nectin1tm1Ytk
Genetic
Background
either: (involves: 129X1/SvJ * C57BL * DBA) or (involves: 129X1/SvJ * BALB/cA * C57BL * DBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation (1 available); any Nectin1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• ciliary epithelia adhere to the lens
• separation of the apex-apex contact between the pigment and non-pigment cell layers of the ciliary epithelia at E16.5, however no impairment of the apicolateral junctions between the pigment epithelia or the apicolateral junctions between the non-pigment epithelia
• ciliary processes are absent
• lenses are somewhat deformed
• eyelids are not fused at E16.5 as in wild-type
• about 30% of pups are born with one or both eyes open
• retinal layers are undulating
• vitreous body is absent




Genotype
MGI:4838217
hm2
Allelic
Composition
Nectin1tm1Ytk/Nectin1tm1Ytk
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation (1 available); any Nectin1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• lower incisors are chalky white
• lower incisors display abnormal wear at the apex
• occlusal surfaces show massive wear resulting in the absence of cusps on the 2nd and 3rd molar
• smaller lower molars in keeping with smaller body size

skeleton
• lower incisors are chalky white
• lower incisors display abnormal wear at the apex
• occlusal surfaces show massive wear resulting in the absence of cusps on the 2nd and 3rd molar
• smaller lower molars in keeping with smaller body size

growth/size/body
• lower incisors are chalky white
• lower incisors display abnormal wear at the apex
• occlusal surfaces show massive wear resulting in the absence of cusps on the 2nd and 3rd molar
• smaller lower molars in keeping with smaller body size

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT cleft lip-palate-ectodermal dysplasia syndrome DOID:0060773 OMIM:225060
J:165548




Genotype
MGI:4838219
cx3
Allelic
Composition
Nectin1tm1Ytk/Nectin1tm1Ytk
Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation (1 available); any Nectin1 mutation (12 available)
Nectin3tm1Ytk mutation (0 available); any Nectin3 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological
• become progressively weaker with age starting at P5

homeostasis/metabolism

integument




Genotype
MGI:4838220
cx4
Allelic
Composition
Nectin1tm1Ytk/Nectin1+
Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation (1 available); any Nectin1 mutation (12 available)
Nectin3tm1Ytk mutation (0 available); any Nectin3 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• unlike human Cleft Lip/Palate-Ectodermal Dysplasia Syndrome 1 (CLPED1) patients, no mice with cleft palate are detected and all teeth are present
• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
• at P10 the crown shape of the upper molars is conical
• at P10 a defect in enamel formation is seen in the upper molars
• at P10 the arrangement of the ameloblasts is abnormal and the ameloblast cell layer is detached from the stratum intermedium cell layer
• at P10 polarization of ameloblasts is impaired and ameloblasts are partially detached from each other
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 cells in the stratum reticulum compartment have abnormal shapes and lack the normal cell junction structures
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium

skeleton
• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
• at P10 the crown shape of the upper molars is conical
• at P10 a defect in enamel formation is seen in the upper molars
• at P10 the arrangement of the ameloblasts is abnormal and the ameloblast cell layer is detached from the stratum intermedium cell layer
• at P10 polarization of ameloblasts is impaired and ameloblasts are partially detached from each other
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 cells in the stratum reticulum compartment have abnormal shapes and lack the normal cell junction structures
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium

growth/size/body
• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
• at P10 the crown shape of the upper molars is conical
• at P10 a defect in enamel formation is seen in the upper molars
• at P10 the arrangement of the ameloblasts is abnormal and the ameloblast cell layer is detached from the stratum intermedium cell layer
• at P10 polarization of ameloblasts is impaired and ameloblasts are partially detached from each other
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 cells in the stratum reticulum compartment have abnormal shapes and lack the normal cell junction structures
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT cleft lip-palate-ectodermal dysplasia syndrome DOID:0060773 OMIM:225060
J:165548




Genotype
MGI:4838221
cx5
Allelic
Composition
Nectin1tm1Ytk/Nectin1tm1Ytk
Nectin3tm1Ytk/Nectin3+
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nectin1tm1Ytk mutation (1 available); any Nectin1 mutation (12 available)
Nectin3tm1Ytk mutation (0 available); any Nectin3 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• unlike human Cleft Lip/Palate-Ectodermal Dysplasia Syndrome 1 (CLPED1) patients, no mice with cleft palate are detected and all teeth are present
• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
• at P10 the crown shape of the upper molars is conical
• at P10 a defect in enamel formation is seen in the upper molars
• at P10 the arrangement of the ameloblasts is abnormal
• at P10 minor ruptures between the ameloblast and stratum intermedium cell layers are detected
• at P10 polarization of ameloblasts is impaired
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium

skeleton
• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
• at P10 the crown shape of the upper molars is conical
• at P10 a defect in enamel formation is seen in the upper molars
• at P10 the arrangement of the ameloblasts is abnormal
• at P10 minor ruptures between the ameloblast and stratum intermedium cell layers are detected
• at P10 polarization of ameloblasts is impaired
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium

growth/size/body
• at P10 the crown shape of the upper molars is conical and a defect in enamel formation is seen
• at P10 the crown shape of the upper molars is conical
• at P10 a defect in enamel formation is seen in the upper molars
• at P10 the arrangement of the ameloblasts is abnormal
• at P10 minor ruptures between the ameloblast and stratum intermedium cell layers are detected
• at P10 polarization of ameloblasts is impaired
• at P10 the stellate reticulum compartment of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 the stratum intermedium cell layer of the epithelial enamel organ of the upper molars is hypoplastic
• at P10 expression analysis indicates abnormalities in the adherens junctions and desmosomes in the stratum intermedium cell layer
• at P10 blood vessels are absent from the stratum intermedium

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT cleft lip-palate-ectodermal dysplasia syndrome DOID:0060773 OMIM:225060
J:165548





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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory