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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Klhl6tm2Sato
targeted mutation 2, Thomas N Sato
MGI:3604876
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Klhl6tm2Sato/Klhl6tm2Sato 		either: (involves: 129P2/OlaHsd * 129T2/SvEms) or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * CD-1) MGI:3605618


Genotype
MGI:3605618
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Klhl6tm2Sato/Klhl6tm2Sato
Genetic
Background		 either: (involves: 129P2/OlaHsd * 129T2/SvEms) or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Klhl6tm2Sato mutation (0 available); any Klhl6 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:101363 )
• impaired development past the immature stage
decreased B cell number ( J:101363 )
• reduced number of B220+ and CD3- B lymphocytes in spleen and peripheral blood
abnormal lymph node germinal center morphology ( J:101363 )
• impaired germinal center formation

hematopoietic system
abnormal B cell differentiation ( J:101363 )
• impaired development past the immature stage
decreased B cell number ( J:101363 )
• reduced number of B220+ and CD3- B lymphocytes in spleen and peripheral blood




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory