Phenotypes associated with this allele

• Allele Symbol: Dusp9^tm1Skey
• Allele Name: targeted mutation 1, Stephen M Keyse
• Allele ID: MGI:3604672
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dusp9^tm1Skey/Dusp9^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3606086
ot2	Dusp9^tm1Skey/Y	involves: 129P2/OlaHsd * C57BL/6J	MGI:3606088

Genotype
MGI:3606086

ht1

• Allelic Composition: Dusp9^tm1Skey/Dusp9⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:101370 )

♀ • in crosses of heterozygous females with wild-type males heterozygous embryos are present at E10.5 but absent at E11.5; however heterozygous females are viable when wild-type females are crossed to hemizygous null males

♀ • tetraploid rescue results in viable heterozygous females

embryo

abnormal spongiotrophoblast layer morphology ( J:101370 )

♀ • at E9.5, the spongiotrophoblast is underdeveloped

abnormal placenta labyrinth morphology ( J:101370 )

♀ • at E10.5, the labyrinth layer is thinner and more compact, maternal erythrocytes are restricted to the maternal side of the labyrinth, and fetal erythrocytes remain in the allantois and chorion

Genotype
MGI:3606088

ot2

• Allelic Composition: Dusp9^tm1Skey/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:101370 )

♂ • hemizygous embryos are present at E10.5 but absent at E11.5

♂ • tetraploid rescue results in viable and fertile hemizygous males with normal testis and liver morphology

embryo

abnormal spongiotrophoblast layer morphology ( J:101370 )

♂ • at E9.5, the spongiotrophoblast is underdeveloped

abnormal placenta labyrinth morphology ( J:101370 )

♂ • at E10.5, the labyrinth layer is thinner and more compact, maternal erythrocytes are restricted to the maternal side of the labyrinth, and fetal erythrocytes remain in the allantois and chorion