All Phenotypes Gabra3<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gabra3^tm1Dgen
targeted mutation 1, Deltagen
MGI:3604586

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Gabra3^tm1Dgen/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:3628538

Allelic Composition	Gabra3^tm1Dgen/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra3^tm1Dgen mutation (1 available); any Gabra3 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased startle reflex ( J:101679 )

• hemizygous mutants displayed an increased startle response to several sound stimulus types including single bursts at 100db

hyperactivity ( J:101679 )

• hemizygous mutants were hyperactive, in that they displayed increased total distance traveled scores on the open field test

• hyperactivity also observed during home cage observations

increased locomotor activity ( J:101679 )

nervous system

decreased prepulse inhibition ( J:101679 )

• hemizygous mutants were significantly impaired in the Startle/PPI task, demonstrating lower prepulse inhibition scores when the prepulse was 90dB preceeding a 110dB startle stimulus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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