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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
S1pr4tm1Dgen
targeted mutation 1, Deltagen
MGI:3604550
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
S1pr4tm1Dgen/S1pr4tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606609
ht2
S1pr4tm1Dgen/S1pr4+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606610


Genotype
MGI:3606609
hm1
Allelic
Composition
S1pr4tm1Dgen/S1pr4tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr4tm1Dgen mutation (1 available); any S1pr4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos die between E10.5 and E12.5, with embryos appearing partially resorbed by E10.5




Genotype
MGI:3606610
ht2
Allelic
Composition
S1pr4tm1Dgen/S1pr4+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr4tm1Dgen mutation (1 available); any S1pr4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• significantly decreased prepulse inhibition when compared with age- and gender-matched wild-type control mice
• heterozygous mice had lower average PPI scores when a 120 db startling stimulus was preceded by a 90 db prepulse





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory