About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gria3tm1Dgen
targeted mutation 1, Deltagen
MGI:3604486
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gria3tm1Dgen/Gria3tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606450
hm2
Gria3tm1Dgen/Gria3tm1Dgen involves: 129P2/OlaHsd * C57BL/6J MGI:3795130
cx3
Gria3tm1Dgen/Gria3tm1Dgen
Gria4spkw1/Gria4spkw1
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J MGI:3795127
ot4
Gria3tm1Dgen/Y involves: 129P2/OlaHsd * C57BL/6 MGI:3628569


Genotype
MGI:3606450
hm1
Allelic
Composition
Gria3tm1Dgen/Gria3tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at 300 days of age body weight, body mass, and/or body weight to length ratios are reduced




Genotype
MGI:3795130
hm2
Allelic
Composition
Gria3tm1Dgen/Gria3tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show no spike wave discharge (SWD)
• with age, no ataxia is observed




Genotype
MGI:3795127
cx3
Allelic
Composition
Gria3tm1Dgen/Gria3tm1Dgen
Gria4spkw1/Gria4spkw1
Genetic
Background
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (5 available)
Gria4spkw1 mutation (4 available); any Gria4 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 3 months of age, mice develop mild to moderate cerebellar ataxia compared to single mutant littermates
• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes

nervous system
• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes




Genotype
MGI:3628569
ot4
Allelic
Composition
Gria3tm1Dgen/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• a higher dose of metrazol is needed to induce a first twitch stage of seizure response compared to wild-type mice
• startle response is decreased in response to high intensity sound stimuli
• prolonged latency in hot plate test

nervous system
• a higher dose of metrazol is needed to induce a first twitch stage of seizure response compared to wild-type mice

integument
• prolonged latency in hot plate test





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/04/2020
MGI 6.15
The Jackson Laboratory