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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Twsg1tm1Dgen
targeted mutation 1, Deltagen
MGI:3604453
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Twsg1tm1Dgen/Twsg1tm1Dgen involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3606675


Genotype
MGI:3606675
hm1
Allelic
Composition
Twsg1tm1Dgen/Twsg1tm1Dgen
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Twsg1tm1Dgen mutation (1 available); any Twsg1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• low body weight/body length ratio trend at 49, 90, 180, and 300 days of age, which is greater in males than females
• low body weight trend at 49, 90, 180, and 300 days of age, which is greater in males than females
• the magnitude of difference between wildtype and homozygotes is greatest at 300 days of age
• body weight decreases after 180 days of age, with differences greater for males than females
• low body length trend at 49, 90, 180, and 300 days of age, which is greater in males than females
• the magnitude of difference between wildtype and homozygotes is greatest at 300 days of age

limbs/digits/tail
• 8 of 16 homozygotes display a kinked tail at 49 days of age, and 1 of 9 at 300 days of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory