• homozygotes are viable and fertile with no change in overall APP levels; however, neuron associated Abeta levels and production of sAPP in the brain are increased at 10 months of age (J:101417)

• increase in levels of amyloid beta peptide in the brain

• increase in levels of amyloid beta peptide in the brain

• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta

• some of the largest differences in amyloid measures are detected in the cerebellum

• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta

• some of the largest differences in amyloid measures are detected in the cerebellum