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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sorl1tm1Tew
targeted mutation 1, Thomas E Willnow
MGI:3604352
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sorl1tm1Tew/Sorl1tm1Tew either: (involves: 129/SvEmcTer * BALB/c) or (involves: 129/SvEmcTer * C57BL/6N) MGI:3607144
hm2
Sorl1tm1Tew/Sorl1tm1Tew involves: 129 * C57BL/6 * SJL MGI:5581428
cx3
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129 * C3H/HeJ * C57BL/6 MGI:5050413
cx4
Sorl1tm1Tew/Sorl1tm1Tew
Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
involves: 129 * C57BL/6 * SJL MGI:5581430


Genotype
MGI:3607144
hm1
Allelic
Composition
Sorl1tm1Tew/Sorl1tm1Tew
Genetic
Background
either: (involves: 129/SvEmcTer * BALB/c) or (involves: 129/SvEmcTer * C57BL/6N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1tm1Tew mutation (0 available); any Sorl1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• homozygotes are viable and fertile with no change in overall APP levels; however, neuron associated Abeta levels and production of sAPP in the brain are increased at 10 months of age (J:101417)
• homozygotes are viable and fertile with no change in overall APP levels; however, neuron associated Abeta levels and production of sAPP in the brain are increased at 10 months of age (J:101417)
• increase in levels of amyloid beta peptide in the brain (J:101417)
• increase in levels of amyloid beta peptide in the brain (J:101417)

homeostasis/metabolism
• increase in levels of amyloid beta peptide in the brain (J:101417)
• increase in levels of amyloid beta peptide in the brain (J:101417)




Genotype
MGI:5581428
hm2
Allelic
Composition
Sorl1tm1Tew/Sorl1tm1Tew
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1tm1Tew mutation (0 available); any Sorl1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 3, 6, and 12-14 months of age, mice do not distinguish between old and new objects in the object recognition test, exploring the new and familiar object equally (J:210074)
• at 3, 6, and 12-14 months of age, mice do not distinguish between old and new objects in the object recognition test, exploring the new and familiar object equally (J:210074)
• although mutants learn a well as wild-type mice during the acquisition phase of the Morris water maze, during the probe phase, 3, 6, and 12-16 month old mutants, are unable to remember the target quadrant (J:210074)
• although mutants learn a well as wild-type mice during the acquisition phase of the Morris water maze, during the probe phase, 3, 6, and 12-16 month old mutants, are unable to remember the target quadrant (J:210074)

homeostasis/metabolism
• amyloid beta immunoreactive dystrophic neurites in the hippocampus are seen at 6 months and in the neocortex at 12 months (J:210074)
• amyloid beta immunoreactive dystrophic neurites in the hippocampus are seen at 6 months and in the neocortex at 12 months (J:210074)

nervous system
• amyloid beta immunoreactive dystrophic neurites in the hippocampus are seen at 6 months and in the neocortex at 12 months (J:210074)
• amyloid beta immunoreactive dystrophic neurites in the hippocampus are seen at 6 months and in the neocortex at 12 months (J:210074)
• phosphorylated tau is seen in neurons of the lateral entorhinal cortex, the neocrotex, and the hippocampus at 3, 6, and 12 months of age; somatodendritic localization of phosphorylated tau is not observed (J:210074)
• phosphorylated tau is seen in neurons of the lateral entorhinal cortex, the neocrotex, and the hippocampus at 3, 6, and 12 months of age; somatodendritic localization of phosphorylated tau is not observed (J:210074)
• decrease in the number of ChAT-positive neurons in the nucleus basalis of Meynert at 6 and 12-14 months of age and in the medial septum/diagonal band of Broca at 3 and 6 months but not at 12-14 months (J:210074)
• decrease in the number of ChAT-positive neurons in the nucleus basalis of Meynert at 6 and 12-14 months of age and in the medial septum/diagonal band of Broca at 3 and 6 months but not at 12-14 months (J:210074)
• degeneration of cholinergic neurons (J:210074)
• degeneration of cholinergic neurons (J:210074)




Genotype
MGI:5050413
cx3
Allelic
Composition
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129 * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1tm1Tew mutation (0 available); any Sorl1 mutation (7 available)
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta (J:142501)
• some of the largest differences in amyloid measures are detected in the cerebellum (J:142501)
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta (J:142501)
• some of the largest differences in amyloid measures are detected in the cerebellum (J:142501)

homeostasis/metabolism
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta (J:142501)
• some of the largest differences in amyloid measures are detected in the cerebellum (J:142501)
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta (J:142501)
• some of the largest differences in amyloid measures are detected in the cerebellum (J:142501)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:142501




Genotype
MGI:5581430
cx4
Allelic
Composition
Sorl1tm1Tew/Sorl1tm1Tew
Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1tm1Tew mutation (0 available); any Sorl1 mutation (7 available)
Tg(CMV-IgkvaD11)BCat mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 3 and 6 months of age, mice do not distinguish between old and new objects in the object recognition test (J:210074)
• at 12-14 months of age, however, the non-spatial memory deficit seen in the object recognition test disappears (J:210074)
• at 3 and 6 months of age, mice do not distinguish between old and new objects in the object recognition test (J:210074)
• at 12-14 months of age, however, the non-spatial memory deficit seen in the object recognition test disappears (J:210074)
• during the acquisition phase of the Morris water maze, 12 month old mutants do not learn as well as wild-type mice (J:210074)
• during the probe phase of the Morris water maze, 3, 6, and 12-14 month old mice are unable to remember the target quadrant (J:210074)
• during the acquisition phase of the Morris water maze, 12 month old mutants do not learn as well as wild-type mice (J:210074)
• during the probe phase of the Morris water maze, 3, 6, and 12-14 month old mice are unable to remember the target quadrant (J:210074)

homeostasis/metabolism
• amyloid beta immunoreactive clusters in dystrophic neurites are seen to a similar extent in the hippocampus as in single Tg(CMV-IgkvaD11)BCat mice at 3 months of age, however by 6 months, the number of amyloid beta immunoreactive clusters is increased two-fold, but then is similar to single transgenics at 12-14 months of age, indicating acceleration of the amyloidogenic process (J:210074)
• amyloid beta immunoreactive clusters in dystrophic neurites are seen to a similar extent in the hippocampus as in single Tg(CMV-IgkvaD11)BCat mice at 3 months of age, however by 6 months, the number of amyloid beta immunoreactive clusters is increased two-fold, but then is similar to single transgenics at 12-14 months of age, indicating acceleration of the amyloidogenic process (J:210074)

nervous system
• amyloid beta immunoreactive clusters in dystrophic neurites are seen to a similar extent in the hippocampus as in single Tg(CMV-IgkvaD11)BCat mice at 3 months of age, however by 6 months, the number of amyloid beta immunoreactive clusters is increased two-fold, but then is similar to single transgenics at 12-14 months of age, indicating acceleration of the amyloidogenic process (J:210074)
• amyloid beta immunoreactive clusters in dystrophic neurites are seen to a similar extent in the hippocampus as in single Tg(CMV-IgkvaD11)BCat mice at 3 months of age, however by 6 months, the number of amyloid beta immunoreactive clusters is increased two-fold, but then is similar to single transgenics at 12-14 months of age, indicating acceleration of the amyloidogenic process (J:210074)
• phosphorylated tau is seen in neurons of the lateral entorhinal cortex, the neocortex and the hippocampus at 12-14 months of age, but not at earlier times; somatodendritic localization of phosphorylated tau is not observed (J:210074)
• phosphorylated tau is seen in neurons of the lateral entorhinal cortex, the neocortex and the hippocampus at 12-14 months of age, but not at earlier times; somatodendritic localization of phosphorylated tau is not observed (J:210074)
• mice show decreased numbers of ChAT-positive neurons only in the medial septum/diagonal band of Broca at 12-14 months of age (J:210074)
• normal numbers of ChAT-positive neurons are seen in the nucleus basalis of Meynert at 3, 6, and 12-14 months of age and in the medial septum/diagonal band of Broca at 3, and 6 months of age, indicating some protection from cholinergic neurodegeneration at early stages (J:210074)
• mice show decreased numbers of ChAT-positive neurons only in the medial septum/diagonal band of Broca at 12-14 months of age (J:210074)
• normal numbers of ChAT-positive neurons are seen in the nucleus basalis of Meynert at 3, 6, and 12-14 months of age and in the medial septum/diagonal band of Broca at 3, and 6 months of age, indicating some protection from cholinergic neurodegeneration at early stages (J:210074)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory