Mouse Genome Informatics
hm1
    Sorl1tm1Tew/Sorl1tm1Tew
either: (involves: 129/SvEmcTer * BALB/c) or (involves: 129/SvEmcTer * C57BL/6N)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• homozygotes are viable and fertile with no change in overall APP levels; however, neuron associated Abeta levels and production of sAPP in the brain are increased at 10 months of age (J:101417)
• increase in levels of amyloid beta peptide in the brain

homeostasis/metabolism
• increase in levels of amyloid beta peptide in the brain


Mouse Genome Informatics
cx2
    Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0

involves: 129 * C3H/HeJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta
• some of the largest differences in amyloid measures are detected in the cerebellum

homeostasis/metabolism
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta
• some of the largest differences in amyloid measures are detected in the cerebellum

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:142501