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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Liastm1Mae
targeted mutation 1, Nobuyo Maeda
MGI:3604218
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Liastm1Mae/Liastm1Mae either: 129S6/SvEvTac-Liastm1Mae or (involves: 129S6/SvEvTac * C57BL/6J) MGI:3604779
ht2
Liastm1Mae/Lias+ either: 129S6/SvEvTac-Liastm1Mae or (involves: 129S6/SvEvTac * C57BL/6J) MGI:3604780
ht3
Liasnehe/Liastm1Mae involves: 129S6/SvEvTac * C57BL/6J MGI:4830284


Genotype
MGI:3604779
hm1
Allelic
Composition
Liastm1Mae/Liastm1Mae
Genetic
Background
either: 129S6/SvEvTac-Liastm1Mae or (involves: 129S6/SvEvTac * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Liastm1Mae mutation (1 available); any Lias mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos die between E7.5 and E9.5
• even with lipoic acid supplementation of the dams no live born homozygotes are found

embryo
• embryos appear to stop growing at the egg cylinder stage
• embryos are smaller at E7.5

growth/size/body
• embryos are smaller at E7.5




Genotype
MGI:3604780
ht2
Allelic
Composition
Liastm1Mae/Lias+
Genetic
Background
either: 129S6/SvEvTac-Liastm1Mae or (involves: 129S6/SvEvTac * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Liastm1Mae mutation (1 available); any Lias mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• levels of glutathione in erythrocytes are significantly reduced; however plasma glucose, triglyceride, and cholesterol levels are normal and no increase in thiobarbituric acid-reactive substances (TBARS, a measure of oxidative stress) is seen




Genotype
MGI:4830284
ht3
Allelic
Composition
Liasnehe/Liastm1Mae
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Liasnehe mutation (0 available); any Lias mutation (21 available)
Liastm1Mae mutation (1 available); any Lias mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mice exhibit anterior truncation compared with wild-type mice
• more severe than in Liasnehe homozygotes

growth/size/body
• more severe than in Liasnehe homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory