All Phenotypes Mapt<tm2Arbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapt^tm2Arbr
targeted mutation 2, Silvia Arber
MGI:3590682

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lbx1^tm2Cbm/Lbx1^{tm3.1(cre)Cbm} Mapt^tm2Arbr/Mapt⁺	involves: 129P2/OlaHsd	MGI:3710960
cn2	Mapt^tm2Arbr/Mapt⁺ Neurod6^tm1(cre)Kan/Neurod6⁺ Trim67^tm1.1Slgu/Trim67^tm1.1Slgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6259603
cn3	Mapt^tm2Arbr/? Runx1^tm3Spe/Runx1^tm3Spe H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J	MGI:5702481
cn4	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:5702479
cn5	Mapt^tm2Arbr/Mapt⁺ Shox2^{tm1.1(cre)Oki}/Shox2⁺ Slc17a6^tm1.1Thna/Slc17a6^tm1.2Edw	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:5576701
cn6	Mapt^tm2Arbr/Mapt⁺ Pvalb^tm1(cre)Arbr/Pvalb⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3716104
cn7	Mapt^tm2Arbr/? Runx1^tm3Spe/Runx1^{tm1(cre/Esr1*)Ims}	involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj	MGI:5702485
cn8	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? Runx1^{tm1(cre/Esr1*)Ims}/?	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	MGI:5702484

Allelic Composition	Lbx1^tm2Cbm/Lbx1^{tm3.1(cre)Cbm} Mapt^tm2Arbr/Mapt⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbx1^tm2Cbm mutation (0 available); any Lbx1 mutation (13 available)
Lbx1^{tm3.1(cre)Cbm} mutation (0 available); any Lbx1 mutation (13 available)
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brainstem morphology ( J:121332 )

• spinal trigeminal nucleus (SpV, trigeminal somatosensory relay nucleus) does not form; Lmx1b+ and Tlx3+ neurons cannot be detected at E14 and 18 in lateral medulla, but such neurons ar abundant in control SpV

abnormal medulla oblongata morphology ( J:121332 )

• ectopic dB3* and dBLb3* neurons are assembled in a broad dorsal band

• absence of SpV causes shape abnormalities in medulla

abnormal neuron morphology ( J:121332 )

• mutants have increased number of tyrosine hydroxylase-positive neurons in dorsal medulla

abnormal neuron differentiation ( J:121332 )

• many ectopic neurons are observed in the ventral alar plate at E10.5

• neurons expressing Phox2b, Lmx1b, and Tlx3, thus diplaying identity of dA3 neurons, arise early in neurogenesis at positions where dB3 neurons are normally generated, and are designated dB3* neurons

• such ectopic neurons (DBLb*) also arise during the late phase of neurogenesis, at the expense of dBLb (late-born dB neurons) whereas Phox2b+ neurons are only generated early in control mice

increased sensory neuron number ( J:121332 )

abnormal neuron specification ( J:121332 )

• dB3 and dBLb neurons are misspecified, and an increased number of ectopic dB3* and dBLb3* neurons with the molecular characteristics of dA3 neurons Lmx1b are seen in mutants vs controls at E14 and settle like dA3 neurons in a broad band in dorsal medulla close to solitary tract

cellular

abnormal neuron differentiation ( J:121332 )

• many ectopic neurons are observed in the ventral alar plate at E10.5

• such ectopic neurons (DBLb*) also arise during the late phase of neurogenesis, at the expense of dBLb (late-born dB neurons) whereas Phox2b+ neurons are only generated early in control mice

Allelic Composition	Mapt^tm2Arbr/Mapt⁺ Neurod6^tm1(cre)Kan/Neurod6⁺ Trim67^tm1.1Slgu/Trim67^tm1.1Slgu
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (17 available)
Trim67^tm1.1Slgu mutation (1 available); any Trim67 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased corpus callosum size ( J:266702 )

• thinner

Allelic Composition	Mapt^tm2Arbr/? Runx1^tm3Spe/Runx1^tm3Spe H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Runx1^tm3Spe mutation (0 available); any Runx1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:226826 )

• reduction of sensory innervtion of the epidermic at P0

abnormal axon morphology ( J:226826 )

• reduction in epidermal nerve fiber density

Allelic Composition	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm2.1Ddg mutation (1 available); any Cbfb mutation (36 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:226826 )

• reduction of sensory innervation of the epidermis at P0

abnormal axon morphology ( J:226826 )

• reduction in epidermal nerve fiber density

abnormal nociceptor morphology ( J:226826 )

• deficiency of peripheral projections of nonpeptidergic (mechanical) nociceptors

craniofacial

abnormal craniofacial development ( J:226826 )

mortality/aging

perinatal lethality ( J:226826 )

• mice die perinatally due to craniofacial defects

Allelic Composition	Mapt^tm2Arbr/Mapt⁺ Shox2^{tm1.1(cre)Oki}/Shox2⁺ Slc17a6^tm1.1Thna/Slc17a6^tm1.2Edw
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Shox2^{tm1.1(cre)Oki} mutation (0 available); any Shox2 mutation (19 available)
Slc17a6^tm1.1Thna mutation (0 available); any Slc17a6 mutation (59 available)
Slc17a6^tm1.2Edw mutation (0 available); any Slc17a6 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:209344 )

• frequencies of locomotor activity induced in isolated spinal cords increase with increasing NMDA concentrations, but are significantly lower than those observed in control spinal cords

• locomotor burst duration increases but duty cycle is not changed in mutant preparations (increased interburst interval)

• coefficients of variation of main locomotor parameters (cycle period, burst duration, amplitude, duty cycle) are increased compared to controls

• spinal cords from mutants display lower drug-evoked and stimulus-evoked locomotor frequencies

• flexor-extensor coupling is not significantly changed at any locomotor frequency

Allelic Composition	Mapt^tm2Arbr/Mapt⁺ Pvalb^tm1(cre)Arbr/Pvalb⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Pvalb^tm1(cre)Arbr mutation (5 available); any Pvalb mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal root ganglion morphology ( J:100886 )

• whole dorsal root ganglia require neurotrophin-3 for survival

Allelic Composition	Mapt^tm2Arbr/? Runx1^tm3Spe/Runx1^{tm1(cre/Esr1*)Ims}
Genetic Background	involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Runx1^{tm1(cre/Esr1*)Ims} mutation (0 available); any Runx1 mutation (35 available)
Runx1^tm3Spe mutation (0 available); any Runx1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal mechanoreceptor morphology ( J:226826 )

• few or no tyrosine hydroxylase C-low threshold mechanoreceptors (C-LTMRs) are observed in P21 mice following tamoxifen administration at P2

• decrease in the number of longitudinal lanceolate endings (characteristic of C-LTMRs) in back hairy skin of P21 mice

Allelic Composition	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? Runx1^{tm1(cre/Esr1*)Ims}/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm2.1Ddg mutation (1 available); any Cbfb mutation (36 available)
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Runx1^{tm1(cre/Esr1*)Ims} mutation (0 available); any Runx1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal mechanoreceptor morphology ( J:226826 )

• few or no tyrosine hydroxylase C-low threshold mechanoreceptors (C-LTMRs) are observed in P21 mice following tamoxifen administration at P2

• decrease in the number of longitudinal lanceolate endings (characteristic of C-LTMRs) in back hairy skin of P21 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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