All Phenotypes Mapt<tm1(Ewsr1/Etv4)Arbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapt^{tm1(Ewsr1/Etv4)Arbr}
targeted mutation 1, Silvia Arber
MGI:3590681

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Isl1^tm1(cre)Tmj/Isl1⁺ Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716103
cn2	Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺ Mnx1^tm4(cre)Tmj/Mnx1⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3716107

Allelic Composition	Isl1^tm1(cre)Tmj/Isl1⁺ Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (33 available)
Mapt^{tm1(Ewsr1/Etv4)Arbr} mutation (0 available); any Mapt mutation (428 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased muscle spindle number ( J:100886 )

• mice have 25% of the wild-type number of muscle spindles

abnormal sensory neuron morphology ( J:100886 )

• while sensory axons reach the skin only rudimentary sensory axon branching is established within the skin

abnormal sensory neuron innervation pattern ( J:100886 )

• sensory afferents fail to invade the spinal cord and are found in an extreme lateral position at the dorsal root entry zone

• sensory afferents are bifurcated at the entry point

• sensory afferent fibers fail to approach the midline at the distal segments and continue to occupy an extreme lateral position

abnormal dorsal root ganglion morphology ( J:100886 )

• unlike wild-type cells, dorsal root ganglia neurons survive in culture without the addition of neurotrophic agents

• whole dorsal root ganglia require neurotrophin-3 for survival

muscle

decreased muscle spindle number ( J:100886 )

• mice have 25% of the wild-type number of muscle spindles

Allelic Composition	Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺ Mnx1^tm4(cre)Tmj/Mnx1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^{tm1(Ewsr1/Etv4)Arbr} mutation (0 available); any Mapt mutation (428 available)
Mnx1^tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:100886 )

• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

cellular

abnormal axon extension ( J:100886 )

• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

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