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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mapttm1(Ewsr1/Etv4)Arbr
targeted mutation 1, Silvia Arber
MGI:3590681
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3716103
cn2
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3716107


Genotype
MGI:3716103
cn1
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Mapttm1(Ewsr1/Etv4)Arbr mutation (0 available); any Mapt mutation (401 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice have 25% of the wild-type number of muscle spindles
• while sensory axons reach the skin only rudimentary sensory axon branching is established within the skin
• sensory afferents fail to invade the spinal cord and are found in an extreme lateral position at the dorsal root entry zone
• sensory afferents are bifurcated at the entry point
• sensory afferent fibers fail to approach the midline at the distal segments and continue to occupy an extreme lateral position
• unlike wild-type cells, dorsal root ganglia neurons survive in culture without the addition of neurotrophic agents
• whole dorsal root ganglia require neurotrophin-3 for survival

muscle
• mice have 25% of the wild-type number of muscle spindles




Genotype
MGI:3716107
cn2
Allelic
Composition
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Ewsr1/Etv4)Arbr mutation (0 available); any Mapt mutation (401 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

cellular
• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory