Mouse Genome Informatics
cn1
    Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+

involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• while sensory axons reach the skin only rudimentary sensory axon branching is established within the skin
• mice have 25% of the wild-type number of muscle spindles
• sensory afferents fail to invade the spinal cord and are found in an extreme lateral position at the dorsal root entry zone
• sensory afferents are bifurcated at the entry point
• sensory afferent fibers fail to approach the midline at the distal segments and continue to occupy an extreme lateral position
• unlike wild-type cells, dorsal root ganglia neurons survive in culture without the addition of neurotrophic agents
• whole dorsal root ganglia require neurotrophin-3 for survival

muscle
• mice have 25% of the wild-type number of muscle spindles


Mouse Genome Informatics
cn2
    Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Mnx1tm4(cre)Tmj/Mnx1+

involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

cellular
• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination