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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm1Thl
targeted mutation 1, Thomas Ludwig
MGI:3589921
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:5008634
cn2
Ptentm2.1Ppp/Ptentm2.1Ppp
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:3603330
cn3
Brca1tm1Thl/Brca1tm3.1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494462
cn4
Brca1tm1Thl/Brca1tm1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494464
cn5
Brca1tm1Thl/Brca1tm2.1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5494465
cn6
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
involves: 129S4/SvJae * FVB/N MGI:5494463
cn7
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
involves: C57BL/6 * DBA/2 MGI:3603329
cn8
Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl
involves: C57BL/6J * CBA/J MGI:5315853


Genotype
MGI:5008634
cn1
Allelic
Composition
Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (310 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (40 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (144 available)
Tyrc-Brd mutation (6 available); any Tyr mutation (366 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

mortality/aging
• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Ptentm1Hwu homozygotes

neoplasm
• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Ptentm1Hwu homozygotes
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells




Genotype
MGI:3603330
cn2
Allelic
Composition
Ptentm2.1Ppp/Ptentm2.1Ppp
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (40 available)
Tg(Pbsn-cre)4Prb mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53

reproductive system
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53

mortality/aging
• all mutants died by 7 months of age

neoplasm
• invasive prostatic cancer is seen in all mutants by 10 weeks of age
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53
• by 11 weeks of age invasive adenocarcinoma develops

renal/urinary system
• bladder obstruction




Genotype
MGI:5494462
cn3
Allelic
Composition
Brca1tm1Thl/Brca1tm3.1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (0 available); any Brca1 mutation (73 available)
Brca1tm3.1Thl mutation (0 available); any Brca1 mutation (73 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)6Tuv mutation (1 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• as in Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thlmice succumb to pancreatic tumors with an average latency of 65 days




Genotype
MGI:5494464
cn4
Allelic
Composition
Brca1tm1Thl/Brca1tm1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (0 available); any Brca1 mutation (73 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)6Tuv mutation (1 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice succumb to pancreatic tumors with an average latency of 68 days




Genotype
MGI:5494465
cn5
Allelic
Composition
Brca1tm1Thl/Brca1tm2.1Thl
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Thl mutation (0 available); any Brca1 mutation (73 available)
Brca1tm2.1Thl mutation (0 available); any Brca1 mutation (73 available)
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)6Tuv mutation (1 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 45 days compared with 68 days in Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thl
• however, latency is similar to in Brca1tm1Thl/Brca1tm1Thl Krastm4Tyj/Kras+ Tg(Ipf1-cre)6Tuv Trp53tm1Thl/Trp53tm1Thl




Genotype
MGI:5494463
cn6
Allelic
Composition
Krastm4Tyj/Kras+
Trp53tm1Thl/Trp53tm1Thl
Tg(Pdx1-cre)6Tuv/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Tg(Pdx1-cre)6Tuv mutation (1 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice succumb to pancreatic tumors with an average latency of 68 days




Genotype
MGI:3603329
cn7
Allelic
Composition
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-cre)4Prb mutation (3 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• no prostatic tumors are detected in 9-week old mutants




Genotype
MGI:5315853
cn8
Allelic
Composition
Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl
Genetic
Background
involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Wgu mutation (0 available); any Huwe1 mutation (61 available)
Tg(Ins2-cre)23Herr mutation (0 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive longer than Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

homeostasis/metabolism
N
• diabetic symptoms (serum glucose and insulin levels and glucose intolerance) observed in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice are improved
• in fasting mice at 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice
• in fed mice at 3, 6 and 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

endocrine/exocrine glands
N
• islet organization is improved compared to in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory