Mouse Genome Informatics
cn1
     Gt(ROSA)26Sortm2Thl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Thl/Trp53tm1Thl
Tyrc-Brd/Tyrc-Brd
involves: 129/Sv * 129S4/SvJae * C57BL/6
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
premature death ( J:172585 )
• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Ptentm1Hwu homozygotes

tumorigenesis
increased tumor growth/size ( J:172585 )
• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Ptentm1Hwu homozygotes
increased glioblastoma incidence ( J:172585 )
• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells


Mouse Genome Informatics
cn2
     Ptentm2.1Ppp/Ptentm2.1Ppp
Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
involves: 129S1/Sv * C57BL/6 * DBA/2
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
premature death ( J:100683 )
• all mutants died by 7 months of age

tumorigenesis
carcinoma ( J:100683 )
• by 11 weeks of age invasive adenocarcinoma develops
increased prostate gland tumor incidence ( J:100683 )
• invasive prostatic cancer is seen in all mutants by 10 weeks of age (J:100683)
• average tumor weight is increased 32-fold compared to mutants wild-type for Trp53 and these tumors encompass the entire genitourinary tract and pelvis (J:100683)
• no increase is seen in the number of senescent cells compared to wild-type prostates unlike in mutants wild-type for Trp53 (J:100683)

renal/urinary system
urinary bladder obstruction ( J:100683 )
• bladder obstruction


Mouse Genome Informatics
cn3
     Trp53tm1Thl/Trp53tm1Thl
Tg(Pbsn-cre)4Prb/0
involves: C57BL/6 * DBA/2
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
tumorigenesis
tumorigenesis ( J:100683 )
N
• no prostatic tumors are detected in 9-week old mutants (J:100683)


Mouse Genome Informatics
cn4
     Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl
involves: C57BL/6J * CBA/J
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
mortality/aging ( J:182446 )
N
• mice survive longer than Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice (J:182446)

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:182446 )
N
• diabetic symptoms (serum glucose and insulin levels and glucose intolerance) observed in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice are improved (J:182446)
hyperglycemia ( J:182446 )
• in fasting mice at 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice (J:182446)
• in fed mice at 3, 6 and 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice (J:182446)

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:182446 )
N
• islet organization is improved compared to in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice (J:182446)