Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81tm1Chmg mutation
(0 available);
any
Mus81 mutation
(29 available)
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mortality/aging
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• homozygotes display increased sensitivity to mitomycin C-induced lethality but did not display premature aging, decreased life spans, or increased tumor incidence
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cellular
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• homozygous MEFs die after 3 - 5 days in culture with a significant decrease in cells with 4N DNA and increase in cells with sub-G1 content of DNA after 2 days in culture; however, homozygous mice are viable and display normal growth, immune function, and fertility
• retroviral expression of the viral protein E6 which promotes degradation of Trp53 allows homozygous MEFs to survive in culture although these cells display increased DNA damage and chromosomal aberrations
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81tm1Chmg mutation
(0 available);
any
Mus81 mutation
(29 available)
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cardiovascular system
N |
• unlike mice homozygous for Mus81tm1Esse, no defects are seen in the aortic wall including the elastin layers
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81tm1Chmg mutation
(0 available);
any
Mus81 mutation
(29 available)
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cellular
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• in mouse embryonic fibroblasts treated with DNA interstrand crosslinking agents (MMC)
• however, MMC-induced increase in sister chromatid exchange frequency is normal in mouse embryonic fibroblasts
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• Blm-depleted mouse embryonic fibroblasts exhibit reduced sister chromatid exchange frequency compared with wild-type cells
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mus81tm1Chmg mutation
(0 available);
any
Mus81 mutation
(29 available)
Slx1btm1.1Jrou mutation
(0 available);
any
Slx1b mutation
(26 available)
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reproductive system
N |
• mice exhibit normal fertility and testes size
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cellular
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• in mouse embryonic fibroblasts treated with DNA interstrand crosslinking agents (MMC) to the same extent as in single homozygotes
• however, MMC-induced increase in sister chromatid exchange frequency is normal in mouse embryonic fibroblasts
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• Blm-depleted mouse embryonic fibroblasts exhibit reduced sister chromatid exchange frequency as in single homozygotes
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1tm1d(KOMP)Wtsi mutation
(0 available);
any
Fan1 mutation
(98 available)
Mus81tm1Chmg mutation
(0 available);
any
Mus81 mutation
(29 available)
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