Phenotypes associated with this allele

• Allele Symbol: Cxadr^tm1Dvst
• Allele Name: targeted mutation 1, Dietmar Vestweber
• Allele ID: MGI:3587803
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxadr^tm1Dvst/Cxadr^tm1Dvst	involves: 129X1/SvJ * C57BL/6	MGI:3588059

Genotype
MGI:3588059

hm1

• Allelic Composition: Cxadr^tm1Dvst/Cxadr^tm1Dvst
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:100174 )

• embryos died between E11.5 and E13.5

cardiovascular system

dilated dorsal aorta ( J:100174 )

• strong dilatations of the aortae

abnormal placental labyrinth vasculature morphology ( J:100174 )

• fetal blood vessels within the labyrinth zone were modestly dilated

abnormal cardinal vein morphology ( J:100174 )

• strong dilatations of the cardinal vein

increased cardiac muscle glycogen level ( J:100174 )

• accumulation of glycogen in cardiomyocytes

abnormal myocardial fiber morphology ( J:100174 )

• lack of close arrangement

• accumulation of glycogen in cardiomyocytes

decreased myocardial fiber size ( J:100174 )

• reduced diameter, 0.3 um in mutants compared to 1-1.5 in wild-type

abnormal fetal atrioventricular canal morphology ( J:100174 )

• one canal was present, rather than two

increased atrioventricular cushion size ( J:100174 )

• displayed at E11.5 due to edema formation

abnormal heart ventricle morphology ( J:100174 )

• the lumen of the ventricles was smaller than wild-type

pericardial edema ( J:100174 )

• demonstrated at E11.5

enlarged pericardium ( J:100174 )

• demonstrated at E11.5

embryo

abnormal placental labyrinth vasculature morphology ( J:100174 )

• fetal blood vessels within the labyrinth zone were modestly dilated

cellular

abnormal mitochondrial morphology ( J:100174 )

• mitochondria were grossly enlarged and shaped in a ring-like fashion

muscle

increased cardiac muscle glycogen level ( J:100174 )

• accumulation of glycogen in cardiomyocytes

abnormal myocardial fiber morphology ( J:100174 )

• lack of close arrangement

• accumulation of glycogen in cardiomyocytes

decreased myocardial fiber size ( J:100174 )

• reduced diameter, 0.3 um in mutants compared to 1-1.5 in wild-type

abnormal sarcomere morphology ( J:100174 )

• shorter length and reduced number of sarcomeres in mutant cardiomyocytes (4-6 in mutants vs 12-15 in wild-type)

homeostasis/metabolism

increased cardiac muscle glycogen level ( J:100174 )

• accumulation of glycogen in cardiomyocytes

pericardial edema ( J:100174 )

• demonstrated at E11.5