Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col8a1tm1Bjro mutation
(0 available);
any
Col8a1 mutation
(21 available)
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vision/eye
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• Descemet's membrane is thinner
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• 12.3% reduction in stroma thickness
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• increased depth of the anterior chamber (324 um vs. 223 um in controls)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col8a1tm1Bjro mutation
(0 available);
any
Col8a1 mutation
(21 available)
Col8a2tm1Bjro mutation
(0 available);
any
Col8a2 mutation
(19 available)
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vision/eye
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• dysgenesis of the anterior segment of the eye
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• banded structures within the Descemet's membrane are completely absent
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• Descemet's membrane is markedly thinner
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• 21.5% reduction in stroma thickness
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• corneal endothelial cells are enlarged and decreased in number and show a decreased ability to proliferate in response to different growth factors in vitro
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• globoid, keratoglobus-like protrusion of the anterior chamber
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• increased depth of the anterior chamber (392 um vs. 223 um in controls)
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