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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Col8a1tm1Bjro
targeted mutation 1, Bjorn R Olsen
MGI:3587610
Summary 2 genotypes


Genotype
MGI:3589470
hm1
Allelic
Composition
Col8a1tm1Bjro/Col8a1tm1Bjro
Genetic
Background
B6.129S4-Col8a1tm1Bjro
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col8a1tm1Bjro mutation (0 available); any Col8a1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Descemet's membrane is thinner
• 12.3% reduction in stroma thickness
• increased depth of the anterior chamber (324 um vs. 223 um in controls)




Genotype
MGI:3589472
cx2
Allelic
Composition
Col8a1tm1Bjro/Col8a1tm1Bjro
Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic
Background
B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col8a1tm1Bjro mutation (0 available); any Col8a1 mutation (21 available)
Col8a2tm1Bjro mutation (0 available); any Col8a2 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• dysgenesis of the anterior segment of the eye
• banded structures within the Descemet's membrane are completely absent
• Descemet's membrane is markedly thinner
• 21.5% reduction in stroma thickness
• corneal endothelial cells are enlarged and decreased in number and show a decreased ability to proliferate in response to different growth factors in vitro
• globoid, keratoglobus-like protrusion of the anterior chamber
• increased depth of the anterior chamber (392 um vs. 223 um in controls)





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory