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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myo7ash1-11J
shaker 1, 11 Jackson
MGI:3587421
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myo7ash1-11J/Myo7ash1-11J 129.B6-Myo7ash1-11J MGI:5312616
hm2
Myo7ash1-11J/Myo7ash1-11J C57BL/6J-Myo7ash1-11J/J MGI:3587422


Genotype
MGI:5312616
hm1
Allelic
Composition
Myo7ash1-11J/Myo7ash1-11J
Genetic
Background
129.B6-Myo7ash1-11J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7ash1-11J mutation (1 available); any Myo7a mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exposed to moderate intensity light show an accumulation of superoxide in rods at a level 3.5 times greater than in wild-type mice (J:181430)
• mutants exposed to moderate intensity light show an accumulation of superoxide in rods at a level 3.5 times greater than in wild-type mice (J:181430)
• mutants exhibit rod photoreceptor degeneration in response to moderate intensity light exposure that is not seen in wild-type mice (J:181430)
• mutants reared under a moderate light/dark cycle, but not dim/dark cycle conditions, develop severe retinal degeneration in less than 6 months (J:181430)
• mutants exhibit rod photoreceptor degeneration in response to moderate intensity light exposure that is not seen in wild-type mice (J:181430)
• mutants reared under a moderate light/dark cycle, but not dim/dark cycle conditions, develop severe retinal degeneration in less than 6 months (J:181430)

vision/eye
• mutants exposed to moderate intensity light show an accumulation of superoxide in rods at a level 3.5 times greater than in wild-type mice (J:181430)
• mutants exposed to moderate intensity light show an accumulation of superoxide in rods at a level 3.5 times greater than in wild-type mice (J:181430)
• mutants exhibit rod photoreceptor degeneration in response to moderate intensity light exposure that is not seen in wild-type mice (J:181430)
• mutants reared under a moderate light/dark cycle, but not dim/dark cycle conditions, develop severe retinal degeneration in less than 6 months (J:181430)
• mutants exhibit rod photoreceptor degeneration in response to moderate intensity light exposure that is not seen in wild-type mice (J:181430)
• mutants reared under a moderate light/dark cycle, but not dim/dark cycle conditions, develop severe retinal degeneration in less than 6 months (J:181430)

Mouse Models of Human Disease
OMIM ID Ref(s)
Usher Syndrome, Type I; USH1 276900 J:181430




Genotype
MGI:3587422
hm2
Allelic
Composition
Myo7ash1-11J/Myo7ash1-11J
Genetic
Background
C57BL/6J-Myo7ash1-11J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7ash1-11J mutation (1 available); any Myo7a mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants exhibit a head tilt from weaning age, approximately 3-4 weeks (J:82238)
• mutants exhibit a head tilt from weaning age, approximately 3-4 weeks (J:82238)
• mutant mice exhibit bidirectional circling behavior from weaning age, at approximately 3-4 weeks (J:82238)
• mutant mice exhibit bidirectional circling behavior from weaning age, at approximately 3-4 weeks (J:82238)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory