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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Park7tm1Xz
targeted mutation 1, Xiaoxi Zhuang
MGI:3586448
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Park7tm1Xz/Park7tm1Xz involves: 129P2/OlaHsd * C57BL/6J MGI:3604390


Genotype
MGI:3604390
hm1
Allelic
Composition
Park7tm1Xz/Park7tm1Xz
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7tm1Xz mutation (0 available); any Park7 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 5 and 11 months of age, homozygotes show an impaired ability to remove a strip of adhesive tape from their forehead; however no difference is seen in performance in the rotarod test
• at 11 months of age, locomotor and rearing activities are reduced in the open field test
• at 11 months of age, locomotor and rearing activities are reduced in the open field test

nervous system
• at 4 months of age stimulated dopamine release is increased and dopamine uptake is faster in the dorsal caudate-putamen; however, no difference in dopamine release or uptakes is seen in the ventral caudate putamen
• at 6 and 11 months of age dopamine levels are increased in the caudate-putamen; however the number of dopaminergic neurons is normal and no obvious signs of neuropathology are seen

homeostasis/metabolism
• at 4 months of age stimulated dopamine release is increased and dopamine uptake is faster in the dorsal caudate-putamen; however, no difference in dopamine release or uptakes is seen in the ventral caudate putamen
• at 6 and 11 months of age dopamine levels are increased in the caudate-putamen; however the number of dopaminergic neurons is normal and no obvious signs of neuropathology are seen

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 7, Autosomal Recessive Early-Onset; PARK7 606324 J:99905





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory