craniofacial

abnormal tooth mineralization ( J:100004 )

• transmission electron microscopy of the enamel matrix of neonatal incisors reveals non-uniformity in the size of the self-assembled amelogenin nanospheres and disruption of the normally evenly-spaced, parallel arrangement of the hydroxyapatite crystallites

abnormal enamel rod pattern ( J:100004 )

• scanning electron micrographs of incisors of 6 week old mice reveal loss of the normal boundary definiton of the rods comprising the enamel and abnormal porosity of the structure formed by the rods

Mouse Models of Human Disease		OMIM ID	Ref(s)
NOT	Amelogenesis Imperfecta, Type IE; AI1E	301200	J:100004