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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd8atm1.1Litt
targeted mutation 1.1, Dan R Littman
MGI:3584478
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd8atm1.1Litt/Cd8atm1.1Litt either: (involves: 129P2/OlaHsd * AKR) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3584484


Genotype
MGI:3584484
hm1
Allelic
Composition
Cd8atm1.1Litt/Cd8atm1.1Litt
Genetic
Background
either: (involves: 129P2/OlaHsd * AKR) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1.1Litt mutation (0 available); any Cd8a mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• expression of Cd8 alpha was reduced about 10-20% but numbers and proportions of CD8 (+) T cells in the periphery, lymph nodes and spleen were normal
• gut intraepithelial lymphocyte CD8(+) T cells were significantly reduced

hematopoietic system
• expression of Cd8 alpha was reduced about 10-20% but numbers and proportions of CD8 (+) T cells in the periphery, lymph nodes and spleen were normal
• gut intraepithelial lymphocyte CD8(+) T cells were significantly reduced





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory