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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TcraTcrbNY8.3)1Pesa
transgene insertion 1, Pere Santamaria
MGI:3584121
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraTcrbNY8.3)1Pesa/0
NOD.Cg-Rag2tm1Fwa Tg(TcraTcrbNY8.3)1Pesa MGI:3618784
tg2
Tg(TcraTcrbNY8.3)1Pesa/? involves: C57BL/6 * NOD * SJL MGI:3584136


Genotype
MGI:3618784
cx1
Allelic
Composition
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraTcrbNY8.3)1Pesa/0
Genetic
Background
NOD.Cg-Rag2tm1Fwa Tg(TcraTcrbNY8.3)1Pesa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (41 available); any Rag2 mutation (78 available)
Tg(TcraTcrbNY8.3)1Pesa mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• females develop diabetes at lower frequencies and later ages than wild-type Rag2 NOD transgenics




Genotype
MGI:3584136
tg2
Allelic
Composition
Tg(TcraTcrbNY8.3)1Pesa/?
Genetic
Background
involves: C57BL/6 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraTcrbNY8.3)1Pesa mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• insulitis at 3 weeks less than in controls
• insulitis at 6 weeks of age significantly greater than in controls

homeostasis/metabolism
• diabetes develops in 26% (males) to 33% (females) of mice
• diabetes slow to develop and moderate

endocrine/exocrine glands
• insulitis at 3 weeks less than in controls
• insulitis at 6 weeks of age significantly greater than in controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:44202





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory