Analysis Tools
homeostasis/metabolism
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• females develop diabetes at lower frequencies and later ages than wild-type Rag2 NOD transgenics
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Allele Symbol Allele Name Allele ID |
Tg(TcraTcrbNY8.3)1Pesa transgene insertion 1, Pere Santamaria MGI:3584121 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females develop diabetes at lower frequencies and later ages than wild-type Rag2 NOD transgenics
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• insulitis at 3 weeks less than in controls
• insulitis at 6 weeks of age significantly greater than in controls
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• diabetes develops in 26% (males) to 33% (females) of mice
• diabetes slow to develop and moderate
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• insulitis at 3 weeks less than in controls
• insulitis at 6 weeks of age significantly greater than in controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:44202 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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