Mouse Genome Informatics
cx1
    Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraTcrbNY8.3)1Pesa/0

NOD.Cg-Rag2tm1Fwa Tg(TcraTcrbNY8.3)1Pesa
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• females develop diabetes at lower frequencies and later ages than wild-type Rag2 NOD transgenics


Mouse Genome Informatics
tg2
    Tg(TcraTcrbNY8.3)1Pesa/?
involves: C57BL/6 * NOD * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• insulitis at 3 weeks less than in controls
• insulitis at 6 weeks of age significantly greater than in controls

homeostasis/metabolism
• diabetes develops in 26% (males) to 33% (females) of mice
• diabetes slow to develop and moderate

endocrine/exocrine glands
• insulitis at 3 weeks less than in controls
• insulitis at 6 weeks of age significantly greater than in controls

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:44202