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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ms4a2tm1Chr
targeted mutation 1, Chisei Ra
MGI:3583705
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ms4a2tm1Chr/Ms4a2tm1Chr involves: 129S1/Sv * 129X1/SvJ MGI:3584138


Genotype
MGI:3584138
hm1
Allelic
Composition
Ms4a2tm1Chr/Ms4a2tm1Chr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ms4a2tm1Chr mutation (0 available); any Ms4a2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in vitro IgE dependent degranulation is absent in both bone marrow mast cells and connective tissue-type mast cells
• in vitro adhesion to fibronectin and Ca2+ flux are increased when bone marrow mast cells are saturated with 2.4G2 and triggered with a second antibody
• in vitro degranulation of connective tissue-type mast cells is decreased when saturated with 2.4G2 and triggered with a second antibody
• passive cutaneous anaphylaxis (PCA) induced by heat-aggregated IgG is reduced and IgE dependent PCA is absent

hematopoietic system
• in vitro IgE dependent degranulation is absent in both bone marrow mast cells and connective tissue-type mast cells
• in vitro adhesion to fibronectin and Ca2+ flux are increased when bone marrow mast cells are saturated with 2.4G2 and triggered with a second antibody
• in vitro degranulation of connective tissue-type mast cells is decreased when saturated with 2.4G2 and triggered with a second antibody





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory