All Phenotypes Sin3a<tm1.1Rdp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sin3a^tm1.1Rdp
targeted mutation 1.1, Ronald DePinho
MGI:3583656

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sin3a^tm1.1Rdp/Sin3a^tm1.1Rdp	involves: 129	MGI:3617474
cx2	Sin3a^tm1.1Rdp/Sin3a⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6 * FVB	MGI:3698865

Allelic Composition	Sin3a^tm1.1Rdp/Sin3a^tm1.1Rdp
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sin3a^tm1.1Rdp mutation (0 available); any Sin3a mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:99406 )

• absent at E6.5

Allelic Composition	Sin3a^tm1.1Rdp/Sin3a⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sin3a^tm1.1Rdp mutation (0 available); any Sin3a mutation (60 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:117829 )

N	• mice show identical tumor incidence, tumor multiplicity, and tumor spectrum to mice with a Sin3a-sufficient, Trp53-null background

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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