All Phenotypes Rec8<tm1Mjm> MGI Mouse

prenatal lethality, incomplete penetrance ( J:99402 )

• only 12% of pups from heterozygous matings are homozygous and at E13.5 only 16% of embryos are homozygous

abnormal seminiferous tubule morphology ( J:99402 )

• more apoptotic cells are seen in the tubules compared to wild-type mice

abnormal female reproductive system morphology ( J:99402 )

• the genital tract is involuted

abnormal ovary morphology ( J:99402 )

• dense fibrovascular stoma is seen

absent ovarian follicles ( J:99402 )

abnormal gametogenesis ( J:99402 )

absent oocytes ( J:99402 )

• complete absence of oocytes

azoospermia ( J:99402 )

• no mature sperm or spermatids are seen and testes are almost depleted of primary spemtocytes by 19 days of age

abnormal female meiosis ( J:99402 )

• homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes

• leptotene chromosomes are seen at E16.5-E18.5 but normal pachytene nuclei are never seen

arrest of male meiosis ( J:99402 )

• homozygous meiocytes fail to complete meiotic prophase I and abnormal synaptonemal complexes form between sister chromatids rather than between homologous chromososmes

• zygotene but not pachytene nuclei are seen

female infertility ( J:99402 )

male infertility ( J:99402 )

postnatal growth retardation ( J:99402 )

decreased fetal size ( J:99402 )

• reduced size at E15.5