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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgl2tm1Pam
targeted mutation 1, Philip A Marsden
MGI:3582343
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fgl2tm1Pam/Fgl2tm1Pam B6.129X1-Fgl2tm1Pam MGI:3583697
hm2
Fgl2tm1Pam/Fgl2tm1Pam involves: 129X1/SvJ * C57BL/6 MGI:3583696
hm3
Fgl2tm1Pam/Fgl2tm1Pam involves: 129X1/SvJ * C57BL/6J MGI:3583699
ht4
Fgl2tm1Pam/Fgl2+ involves: 129X1/SvJ * C57BL/6 MGI:3583698


Genotype
MGI:3583697
hm1
Allelic
Composition
Fgl2tm1Pam/Fgl2tm1Pam
Genetic
Background
B6.129X1-Fgl2tm1Pam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgl2tm1Pam mutation (0 available); any Fgl2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• resistant to murine hepatitis virus type 3 (MHV-3) induced death

immune system
• resistant to murine hepatitis virus type 3 (MHV-3) induced liver necrosis
• resistant to murine hepatitis virus type 3 (MHV-3) induced death




Genotype
MGI:3583696
hm2
Allelic
Composition
Fgl2tm1Pam/Fgl2tm1Pam
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgl2tm1Pam mutation (0 available); any Fgl2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• esistant to murine hepatitis virus type 3 (MHV-3) induced death
• partial lethality between E8.5 and E10.5, with 40% lost when checked at weaning

immune system
• resistant to murine hepatitis virus type 3 (MHV-3) induced liver necrosis
• esistant to murine hepatitis virus type 3 (MHV-3) induced death

homeostasis/metabolism
• MHV-3 infection failed to induce procoagulant activity in thioglycollate-elicited peritoneal macarophages

cardiovascular system
• many E8.5 embryos show moderate to severe hemorrhage at implantation sites, with extravasation of maternal erythrocytes between the mural trophectoderm and Reichert's membrane




Genotype
MGI:3583699
hm3
Allelic
Composition
Fgl2tm1Pam/Fgl2tm1Pam
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgl2tm1Pam mutation (0 available); any Fgl2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• heart grafts from homozygotes transplanted into BALB/cJ mice show a prolonged survival compared to controls but are eventually rejected




Genotype
MGI:3583698
ht4
Allelic
Composition
Fgl2tm1Pam/Fgl2+
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgl2tm1Pam mutation (0 available); any Fgl2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• decreased susceptibility to murine hepatitis virus type 3 (MHV-3) infection





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory