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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd207tm2.1Mal
targeted mutation 1.1, Bernard Malissen
MGI:3581825
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Cd207tm2.1Mal/Cd207tm3.1(HBEGF/EGFP)Mal involves: 129S2/SvPas MGI:3582567


Genotype
MGI:3582567
ht1
Allelic
Composition
Cd207tm2.1Mal/Cd207tm3.1(HBEGF/EGFP)Mal
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd207tm2.1Mal mutation (3 available); any Cd207 mutation (20 available)
Cd207tm3.1(HBEGF/EGFP)Mal mutation (2 available); any Cd207 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no effect of diphtheria toxin-induced Langerhans cell depletion was seen on dinitrofluorobenzene-induced skin contact hypersensitivity
• injection of 1 ug of diphtheria toxin results in 93% and 70% reduction in the number of Langerhans cell derived dendritic cells and CD8alpha+ dendritic cells in the cutaneous lymph nodes
• intraperitoneal injection of 100 ng of diphtheria toxin results in complete elimination of epidermal Langerhans cell by 24 hours after treatment, this persisted for 6-7 days and complete recovery was seen around 14 days after treatment

hematopoietic system
• no effect of diphtheria toxin-induced Langerhans cell depletion was seen on dinitrofluorobenzene-induced skin contact hypersensitivity
• injection of 1 ug of diphtheria toxin results in 93% and 70% reduction in the number of Langerhans cell derived dendritic cells and CD8alpha+ dendritic cells in the cutaneous lymph nodes
• intraperitoneal injection of 100 ng of diphtheria toxin results in complete elimination of epidermal Langerhans cell by 24 hours after treatment, this persisted for 6-7 days and complete recovery was seen around 14 days after treatment





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory