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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ppargtm1Lja
targeted mutation 1, J Larry Jameson
MGI:3580102
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ppargtm1Lja/Ppargtm1Lja involves: 129S1/Sv * 129X1/SvJ MGI:3580110
ht2
Ppargtm1Lja/Pparg+ involves: 129S1/Sv * 129X1/SvJ MGI:3580111


Genotype
MGI:3580110
hm1
Allelic
Composition
Ppargtm1Lja/Ppargtm1Lja
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Lja mutation (0 available); any Pparg mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Embryonic lethality of Ppargtm1Lja/Ppargtm1Lja mice

mortality/aging

embryogenesis
• smaller at E10.5-11.5

growth/size/body
• smaller at E10.5-11.5




Genotype
MGI:3580111
ht2
Allelic
Composition
Ppargtm1Lja/Pparg+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Lja mutation (0 available); any Pparg mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hepatic steatosis in Ppargtm1Lja/Pparg+ mice

adipose tissue
• reduced fat mass
• brown adipocytes contained large multiloculated fat vacuoles not present in wildtype
• epididymal white adipose tissue contained a heterogeneous population of adipocytes with mostly small and medium sized cells, compared to the homozygous population of large adipocytes in wildtype
• reduced epididymal white adipose tissue depots
• exhibited lipodystrophy

growth/size/body
• heterozygous mutants gained less weight on a standard or high fat diet than wildtype after 3 months of age, however no differences in food intake or oxygen consumption

homeostasis/metabolism
• males on a high-fat diet exhibited basal hyperinsulinemia
• exhibited higher serum free fatty acid levels on a standard diet than wildtype
• males on a high-fat diet exhibited insulin resistance, as evidenced by lower glucose infusion rates and impaired glucose uptake in skeletal muscle during clamp studies
• significantly lower levels of serum adiponectin levels than in wildtype on either a standard or high fat diet
• hepatic triglyceride levels were 1.8-fold greater on a standard diet and 1.46-fold greater on a high-fat diet compared to wildtype

muscle
• males on a high-fat diet display impaired glucose uptake in skeletal muscle during clamp studies

liver/biliary system
• hepatic triglyceride levels were 1.8-fold greater on a standard diet and 1.46-fold greater on a high-fat diet compared to wildtype
• 5 month old males exhibited macrovesicular fatty changes in midzonal and centrilobular locations and microvesicular fatty changes around the central vein, indicating hepatic steatosis

cardiovascular system
• females, but not males, were overtly hypertensive on either the standard or high-fat diet

cellular
• males on a high-fat diet display impaired glucose uptake in skeletal muscle during clamp studies





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory