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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itgadtm1Bll
targeted mutation 1, Christie M Ballantyne
MGI:3579559
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itgadtm1Bll/Itgadtm1Bll B6.129S7-Itgadtm1Bll MGI:3583102


Genotype
MGI:3583102
hm1
Allelic
Composition
Itgadtm1Bll/Itgadtm1Bll
Genetic
Background
B6.129S7-Itgadtm1Bll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgadtm1Bll mutation (1 available); any Itgad mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice

immune system
• SEA injection induced less of a decrease in the numbers of thymocytes than in wild-type
• significantly lower ratio of CD4+ to CD8+ cells in splenocytes and thymocytes
• decreased numbers of CD4+ cells in splenocytes and thymocytes
• increased numbers of CD8+ cells in splenocytes and thymocytes
• splenocytes responded poorly to PHA and ConA stimulation, indicating poor T cell activation
• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice

hematopoietic system
• SEA injection induced less of a decrease in the numbers of thymocytes than in wild-type
• significantly lower ratio of CD4+ to CD8+ cells in splenocytes and thymocytes
• decreased numbers of CD4+ cells in splenocytes and thymocytes
• increased numbers of CD8+ cells in splenocytes and thymocytes
• splenocytes responded poorly to PHA and ConA stimulation, indicating poor T cell activation
• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory