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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgadtm1Bll
targeted mutation 1, Christie M Ballantyne
MGI:3579559
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itgadtm1Bll/Itgadtm1Bll B6.129S7-Itgadtm1Bll MGI:3583102


Genotype
MGI:3583102
hm1
Allelic
Composition		 Itgadtm1Bll/Itgadtm1Bll
Genetic
Background		 B6.129S7-Itgadtm1Bll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgadtm1Bll mutation (1 available); any Itgad mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte cell number ( J:90954 )
• SEA injection induced less of a decrease in the numbers of thymocytes than in wild-type
abnormal T cell subpopulation ratio ( J:90954 )
• significantly lower ratio of CD4+ to CD8+ cells in splenocytes and thymocytes
decreased CD4-positive, alpha-beta T cell number ( J:90954 )
• decreased numbers of CD4+ cells in splenocytes and thymocytes
increased CD8-positive, alpha-beta T cell number ( J:90954 )
• increased numbers of CD8+ cells in splenocytes and thymocytes
abnormal T cell activation ( J:90954 )
• splenocytes responded poorly to PHA and ConA stimulation, indicating poor T cell activation
decreased T cell proliferation ( J:90954 )
• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice

hematopoietic system
abnormal lymphocyte cell number ( J:90954 )
• SEA injection induced less of a decrease in the numbers of thymocytes than in wild-type
abnormal T cell subpopulation ratio ( J:90954 )
• significantly lower ratio of CD4+ to CD8+ cells in splenocytes and thymocytes
decreased CD4-positive, alpha-beta T cell number ( J:90954 )
• decreased numbers of CD4+ cells in splenocytes and thymocytes
increased CD8-positive, alpha-beta T cell number ( J:90954 )
• increased numbers of CD8+ cells in splenocytes and thymocytes
abnormal T cell activation ( J:90954 )
• splenocytes responded poorly to PHA and ConA stimulation, indicating poor T cell activation
decreased T cell proliferation ( J:90954 )
• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice

cellular
decreased T cell proliferation ( J:90954 )
• reduced staphylococcal enterotoxin A, B or E (SEA, SEB, SEE)-induced T cell proliferation in splenocytes compared to wild-type and was even more decreased than in homozygous Itgal mutant mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory