Phenotypes associated with this allele
nervous system
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• elevated Amyloid beta in females mice
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrntm1Rwb mutation
(1 available);
any
Agrn mutation
(101 available)
Tg(NPHS2-cre)295Lbh mutation
(3 available)
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|
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renal/urinary system
N |
• when compared to normal controls, no pathological changes are detected until at least 8 months of age
• glomerular filtration barrier is not compromised in mutants, with normal urinary protein and creatinine levels up to 10 months of age when compared to controls
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• at ~4 months of age, glomerular basement membrane (GBM) abnormalities including focal thickening and epithelial protrusions of GBM material are observed in mutants
|
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• focal thickening of the GBM is noted at ~4 months of age
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrntm1Rwb mutation
(1 available);
any
Agrn mutation
(101 available)
Tg(Pax3-cre)1Joe mutation
(0 available)
|
|
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mortality/aging
nervous system
|
• diaphragms lack neuromuscular junctions
|
muscle
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• diaphragms lack neuromuscular junctions
|
nervous system
N |
• expression of the Agrn gene is restricted to endothelial cells
• no obvious failure of integrity in the blood-brain barrier
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cardiovascular system
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• decreased diameter of microvessels
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