All Phenotypes H2<k> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

H2^k
k variant
MGI:3579322

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2^k/H2^k	NOD.Cg-H2^k	MGI:3628776
ht2	H2^k/H2^g7	NOD.Cg-H2^k	MGI:3628792
cx3	H2^b/H2^k Itk^tm1Ljb/Itk^tm1Ljb Tg(TcrAND)53Hed/?	involves: C3H/HeJ * C57BL/6 * C57BL/10	MGI:4354598
cx4	H2^b/H2^k Tg(TcraTcrb)1100Mjb/?	involves: C57BL/6 * C57BL/10Sg * C57BR/c	MGI:3783836
cx5	H2^k/H2^k Tg(TcraTcrbAD10)1Hed/?	involves: C57BL/6 * SJL	MGI:3835452

Allelic Composition	H2^k/H2^k
Genetic Background	NOD.Cg-H2^k

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^k mutation (15 available); any H2 mutation (280 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:14178 )

• after cyclophosphamide treatment, mice develop diabetes at 6-7 months of age

endocrine/exocrine glands

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-8 months of age; with cyclophosphamide treatment, a 6-7 months of age, mild periinsulitis is seen

immune system

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-8 months of age; with cyclophosphamide treatment, a 6-7 months of age, mild periinsulitis is seen

increased susceptibility to autoimmune diabetes ( J:14178 )

• by 7 months of age, no mice develop diabetes; between 9-17 months of age, some mice develop diabetes

Allelic Composition	H2^k/H2^g7
Genetic Background	NOD.Cg-H2^k

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^g7 mutation (24 available); any H2 mutation (280 available)
H2^k mutation (15 available); any H2 mutation (280 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months

Allelic Composition	H2^b/H2^k Itk^tm1Ljb/Itk^tm1Ljb Tg(TcrAND)53Hed/?
Genetic Background	involves: C3H/HeJ * C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (28 available); any H2 mutation (280 available)
H2^k mutation (15 available); any H2 mutation (280 available)
Itk^tm1Ljb mutation (0 available); any Itk mutation (48 available)
Tg(TcrAND)53Hed mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:123795 )

• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA

• expression of CD5, which is correlated with TCR signal strength, is also decreased

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice

hematopoietic system

abnormal positive T cell selection ( J:123795 )

• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA

• expression of CD5, which is correlated with TCR signal strength, is also decreased

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice

Allelic Composition	H2^b/H2^k Tg(TcraTcrb)1100Mjb/?
Genetic Background	involves: C57BL/6 * C57BL/10Sg * C57BR/c

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands

small thymus ( J:133645 )

• the thymus is smaller than normal

Allelic Composition	H2^k/H2^k Tg(TcraTcrbAD10)1Hed/?
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^k mutation (15 available); any H2 mutation (280 available)
Tg(TcraTcrbAD10)1Hed mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD4-positive, alpha-beta T cell number ( J:124701 )

• CD4 single-positive thymocytes make up 37% of the total thymocyte population, which is 3-4 fold greater than controls

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:124701 )

• CD4 single-positive thymocytes make up 37% of the total thymocyte population, which is 3-4 fold greater than controls

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